ADVANCED NEUROMODULATION: DISRUPTIVE DEVELOPMENTS IMPACTING GLOBAL MARKETS

200 Pages | 60 Exhibits | 2018 Analysis Product Family: Market Reports




OVERVIEW:


TABLE OF CONTENTS:
EXECUTIVE SUMMARY

1.0 OVERVIEW OF NEUROMODULATION APPROACHES & APPLICATION SITES

1.1 Approaches
	1.1.1 Neurostimulation
	1.1.2 Neuroblocking
	1.1.3 Selective Denervation
1.2 Application Sites
	1.2.1 CNS
	1.2.2 Peripheral Nerves
1.3 New Direction: Reactivation of Native Homeostasis Processes
	1.3.1 Overview of Native Homeostasis Mechanism: Components and Parameters Monitored
	1.3.2 Vagus Nerve Functional Anatomy and Role in Homeostasis Processes
	1.3.3 Therapeutic Targets, Clinical Benefits & Devices/Drugs Impacted

2.0 ESTABLISHED APPLICATIONS FOR NEUROMODULATION

2.1 Chronic Pain Management (Spinal Cord Stimulation)
	2.1.1 Mechanism of Treatment
	2.1.2 Clinical Evidence
	2.1.3 Targeted Caseloads
	2.1.4 Treated Caseloads
2.2 Neurological Disorders (Deep Brain Stimulation)
	2.2.1 Mechanism of Treatment
	2.2.2 Clinical Evidence
	2.2.3 Targeted Caseloads
	2.2.4 Treated Caseloads
2.3 Incontinence (Sacral Nerve Stimulation)
	2.3.1 Mechanism of Treatment
	2.3.2 Clinical Evidence
	2.3.3 Targeted Caseloads
	2.3.4 Treated Caseloads
2.4 Irreversible Deafness (Cochlear Implants)- 
	2.4.1 Mechanism of Treatment
	2.4.2 Clinical Evidence
	2.4.3 Targeted Caseloads
	2.4.4 Treated Caseloads
2.5 Phrenic Nerve Stimulation (Diaphragm Pacing)
	2.5.1 Mechanism of Treatment
	2.5.2 Clinical Evidence
	2.5.3 Targeted Caseloads
	2.5.4 Treated Caseloads

3.0 EMERGING APPLICATIONS FOR NEUROMODULATION

3.1 Neurological Disorders
	3.1.1 Drug-Refractory Epilepsy
		3.1.1.1 Mechanism of Treatment
		3.1.1.2 Clinical Evidence
		3.1.1.3 Targeted Caseloads
	3.1.2 Cluster Headache & Migraine
		3.1.2.1 Mechanism of Treatment
		3.1.2.2 Clinical Evidence
		3.1.2.3 Targeted Caseloads
	3.1.3 Drug-Resistant Chronic Depression
		3.1.3.1 Mechanism of Treatment
		3.1.3.2 Clinical Evidence
		3.1.3.3 Targeted Caseloads
	3.1.4 Alzheimer's
		3.1.3.1 Mechanism of Treatment
		3.1.3.2 Clinical Evidence
		3.1.3.3 Targeted Caseloads
3.2 Autoimmune Inflammatory Disorders
	3.2.1 Rheumatoid Arthritis
		3.2.1.1 Mechanism of Treatment
		3.2.1.2 Clinical Evidence
		3.2.1.3 Targeted Caseloads
	3.2.2 Crohn's Disease
		3.2.2.1 Mechanism of Treatment
		3.2.2.2 Clinical Evidence
		3.2.2.3 Targeted Caseloads
	3.2.3 Multiple Sclerosis
		3.2.3.1 Mechanism of Treatment
		3.2.3.2 Clinical Evidence
		3.2.3.3 Targeted Caseloads
3.3 Cardiovascular Disorders
	3.3.1 Heart Failure
		3.3.1.1 Mechanism of Treatment
		3.3.1.2 Clinical Evidence
		3.3.1.3 Targeted Caseloads
	3.3.2 Drug-Refractory Hypertension (Renal Denervation)
		3.3.2.1 Mechanism of Treatment
		3.3.2.2 Clinical Evidence
		3.3.2.3 Targeted Caseloads
3.4 Major/Catastrophic Blood Loss
	3.4.1 Mechanism of Treatment
	3.4.2 Clinical Evidence
	3.4.3 Targeted Caseloads
3.5 Metabolic Disorders
	3.5.1 Obesity
		3.5.1.1 Mechanism of Treatment
		3.5.1.2 Clinical Evidence
		3.5.1.3 Targeted Caseloads
	3.5.2 Type 2 Diabetes
		3.5.2.1 Mechanism of Treatment
		3.5.2.2 Clinical Evidence
		3.5.2.3 Targeted Caseloads
3.6 Sleep Apnea
	3.6.1 Mechanism of Treatment
	3.6.2 Clinical Evidence
	3.6.3 Targeted Caseloads
3.7 Incontinence (Overactive Bladder)
	3.7.1 Mechanism of Treatment
	3.7.2 Clinical Evidence
	3.7.3 Targeted Caseloads
3.8 Autism
	3.8.1 Mechanism of Treatment
	3.8.2 Clinical Evidence
	3.8.3 Targeted Caseloads
3.9 Chronic Tinnitus
	3.9.1 Mechanism of Treatment
	3.9.2 Clinical Evidence
	3.9.3 Targeted Caseloads
3.10 Photodegenerative Blindness (Retinal and Visual Prostheses)
	3.10.1 Mechanism of Action
	3.10.2 Clinical Evidence
	3.10.3 Targeted Caseloads
3.11 Opioid Withdrawal Symptoms
	3.11.1 Mechanism of Action
	3.11.2 Clinical Evidence
	3.11.3 Targeted Caseloads

4.0 PRODUCTS & TECHNOLOGIES

4.1 Neurological Conditions
	4.1.1 Drug Refractory Epilepsy
		4.1.1.1 Bionic Enterprises
		4.1.1.2 Cerbomed
		4.1.1.3 CerebralRX
		4.1.1.4 LivaNova
		4.1.1.5 NeuroPace
		4.1.1.6 NeuroSigma
		4.1.1.7 PINS Medical
	4.1.2 Drug Resistant Depression
		4.1.2.1 BrainsWay
		4.1.2.2 Cerbomed
		4.1.2.3 CerebralRx
		4.1.2.4 Endonova Therapeutics
		4.1.2.5 LivaNova
		4.1.2.6 MagVenture
		4.1.2.7 Neuronetics
		4.1.2.8 Tal Medical
	4.1.3 Migraine/Cluster Headache
		4.1.3.1 Automomic Technologies
		4.1.3.2 Cephaly Technology
		4.1.3.3 Cerbomed
		4.1.3.4 electroCore
		4.1.3.5 eNeura
		4.1.3.6 Scion NeuroStim
	4.1.4 Neurodegenerative Disorders
		4.1.4.1 Aleva Neurotherapeutics
		4.1.4.2 Bioinduction
		4.1.4.3 Functional Neuromodulation
		4.1.4.4 Neuronix
4.2 Chronic Pain (ex Headache)
	4.2.1 BioElectronic Corporation
	4.2.2 BlueWind Medical
	4.2.3 Cerbomed
	4.2.4 Mainstay Medical
	4.2.5 NeuroMetrix
	4.2.6 Nevro
	4.2.7 Saluda Medical
	4.2.8 SPR Therapeutics
	4.2.9 Stimwave
4.3 Autoimmune Inflammatory Conditions (SetPoint Medical)
	4.3.1 Rheumatoid Arthritis
	4.3.2 Crohn's Disease
4.4 Hematologic Disorders (Sanguistat)
4.5 Metabolic Disorders: Obesity
	4.5.1 University of Saint Etienne Medical Center
	4.5.2 Federal University of Sao Paulo
4.6 Cardiovascular Disorders: Heart Failure
	4.6.1 BioControl Medical
	4.6.2 Cardionomic
	4.6.3 CVRx
	4.6.4 Enopace Medical
	4.6.5 Impulse Dynamics
	4.6.6 LivaNova
	4.6.7 Oklahoma State University Health Sciences Center
4.7 Urologic Disorders
	4.7.1 Axonics Modulation Technologies
	4.7.2 BlueWind Medical
	4.7.3 Cogentix Medical
	4.7.4 FemPulse LLC
4.8 Sleep Disorders
	4.8.1 Inspire Medical
	4.8.2 LivaNova/ImThera Medical
	4.8.3 Respicardia
4.9 Breathing Disorders: Respiratory Insufficiency
4.10 Opioid Withdrawal Symptoms
4.11 Autism
4.12 Hearing Disorders
	4.12.1 Deafness (Cochlear Implants)
		4.12.1.1 Cochlear
		4.12.1.2 MED-EL
		4.12.1.3 Sonova
		4.12.1.4 William Demant
	4.12.2 Chronic Tinnitus
		4.12.2.1 CorTec/Wyss Center
		4.12.2.2 MicroTransponder
4.13 Photodegenerative Blindness
	4.13.1 Aachen University
	4.13.2 Boston Retinal Implant Project
	4.13.3 Intelligent Medical Implants
	4.13.4 Nidek
	4.13.5 Optobionics
	4.13.6 Second Sight
	4.13.7 Seoul National University
	4.13.8 Stanford University
	4.13.9 University of Melbourne
	4.13.10 University of Tubingen

5.0 MARKETS BY APPROACH AND CLINICAL APPLICATION

5.1 Neurological Disorders
	5.1.1 Parkinson's/Essential Tremor/Alzheimer's (Deep Brain Stimulation)
	5.1.2 Drug-Refractory Epilepsy
	5.1.3 Major Depressive Disorder
	5.1.4 Migraine/Cluster Headache
5.2 Hematologic Disorders (Post-Partum Hemorrhage)
5.3 AutoImmune Inflammatory Disorders
5.4 Chronic Widespread Pain (ex Headache)
5.5 Cardiovascular Disorders (Heart Failure, Refractory Hypertension))
5.6 Incontinence
5.7 Sleep Apnea
5.8 Respiratory Insufficiency (Diaphragm Pacing)
5.9 Hearing Disorders 
	5.9.1 Deafness
	5.9.2 Chronic Tinnitus
5.10 Photodegenerative Blindness
5.11 Autism
5.12 Opioid Withdrawal Symptoms

6.0 MARKETS BY MAJOR GEOGRAPHY

6.1 United States
6.2 Major Europe
6.3 Major Asia
6.4 Rest of World

7.0 COMPANY PROFILES

7.1 Abbott Laboratories (St. Jude Medical)
7.2 Aleva Neurotherapeutics
7.3 Alfred Mann Foundation
7.4 Atrotech Oy
7.5 Autonomic Technologies
7.6 Avery Biomedical
7.7 Axonics Modulation Technologies
7.8 BioControl Medical
7.9 BioElectronics Corporation
7.10 Bioinduction/Finetech Medical
7.11 Bioness
7.12 Bionic Enterprises
7.13 BlueWind Medical
7.14 Boston Scientific Corporation
7.15 BrainsWay
7.16 Burke Medical Research Institute
7.17 Cala Health
7.18 Cardionomic
7.19 Cephaly Technology (STX-Med)
7.20 Cerbomed GmbH
7.21 CerebralRx
7.22 Clinatec
7.23 Cochlear
7.24 Cogentix Medical
7.25 CorTec/Wyss Center
7.26 CVRx
7.27 Deep Brain Innovations
7.28 Defense Advanced Research Projects Agency
7.29 electroCore
7.30 Endonovo Therapeutics
7.31 EndoStim
7.32 eNeura
7.33 Enopace Medical
7.34 Feinstein Institute for Medical Research (Northwell Health)
7.35 FemPulse LLC
7.36 Functional Neuromodulation
7.37 Galvani Bioelectronics
7.38 Hanger
7.39 Hobart Group (Lavita, MetaCure, Renal Dynamics, Impulse Dynamics)
7.40 Innovative Health Solutions
7.41 Inspire Medical Systems
7.42 Intelligent Medical Implants
7.43 IntraPace
7.44 Laboratoire MXM (Axonic Neuromodulation Systems)
7.45 LivaNova (Cyberonics, ImThera)
7.46 MagVenture
7.47 Mainstay Medical
7.48 MED-EL
7.49 Medtronic
7.50 Micro Transponder
7.51 Neurolief
7.52 NeuroMetrix
7.53 Neuronetics
7.54 Neuronix
7.55 NeuroPace
7.56 NeuroSigma
7.57 Neuros Medical
7.58 NeuroTech International Ltd./AAT Research Ltd.
7.59 NeuroTronik
7.60 Nevro
7.61 Nexeon Medsystems/Nuviant Medical
7.62 NIDEK
7.63 Nuvectra
7.64 Optobionics
7.65 Ottobock
7.66 (Beijing) PINS Medical
7.67 ReShape Lifesciences (EnteroMedics)
7.68 Respicardia
7.69 Saluda Medical
7.70 Sanguistat
7.71 SceneRay
7.72 Scion NeuroStim
7.73 Second Sight
7.74 SetPoint Medical
7.75 Sonova
7.76 SPR Therapeutics
7.77 Stimwave
7.78 Synapse Biomedical
7.79 Tal Medical
7.80 CHUs Jean Monnet &Saint Etienne/Life Medical Control/NBA Techno
7.81 University of California Berkeley 
7.82 William Demant 


COMPANIES COVERED:

  1. Abbott Laboratories (St. Jude Medical)
  2. Aleva Neurotherapeutics
  3. Alfred Mann Foundation
  4. Atrotech Oy
  5. Autonomic Technologies
  6. Avery Biomedical
  7. Axonics Modulation Technologies
  8. BioControl Medical
  9. BioElectronics Corporation
  10. Bioinduction/Finetech Medical
  11. Bioness
  12. Bionic Enterprises
  13. BlueWind Medical
  14. Boston Scientific Corporation
  15. BrainsWay
  16. Burke Medical Research Institute
  17. Cala Health
  18. Cardionomic
  19. Cephaly Technology (STX-Med)
  20. Cerbomed GmbH
  21. CerebralRx
  22. Clinatec
  23. Cochlear
  24. Cogentix Medical
  25. CorTec/Wyss Center
  26. CVRx
  27. Deep Brain Innovations
  28. Defense Advanced Research Projects Agency
  29. electroCore
  30. Endonovo Therapeutics
  31. EndoStim
  32. eNeura
  33. Enopace Medical
  34. Feinstein Institute for Medical Research (Northwell Health)
  35. FemPulse LLC
  36. Functional Neuromodulation
  37. Galvani Bioelectronics
  38. Hanger
  39. Hobart Group (Lavita, MetaCure, Renal Dynamics, Impulse Dynamics)
  40. Innovative Health Solutions
  41. Inspire Medical Systems
  42. Intelligent Medical Implants
  43. IntraPace
  44. Laboratoire MXM (Axonic Neuromodulation Systems)
  45. LivaNova (Cyberonics, ImThera)
  46. MagVenture
  47. Mainstay Medical
  48. MED-EL
  49. Medtronic
  50. Micro Transponder
  51. Neurolief
  52. NeuroMetrix
  53. Neuronetics
  54. Neuronix
  55. NeuroPace
  56. NeuroSigma
  57. Neuros Medical
  58. NeuroTech International Ltd./AAT Research Ltd.
  59. NeuroTronik
  60. Nevro
  61. Nexeon Medsystems/Nuviant Medical
  62. NIDEK
  63. Nuvectra
  64. Optobionics
  65. Ottobock
  66. (Beijing) PINS Medical
  67. ReShape Lifesciences (EnteroMedics)
  68. Respicardia
  69. Saluda Medical
  70. Sanguistat
  71. SceneRay
  72. Scion NeuroStim
  73. Second Sight
  74. SetPoint Medical
  75. Sonova
  76. SPR Therapeutics
  77. Stimwave
  78. Synapse Biomedical
  79. Tal Medical
  80. CHUs Jean Monnet &Saint Etienne/Life Medical Control/NBA Techno
  81. University of California Berkeley
  82. William Demant
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