Device-based options that provide anatomic solutions with low physiologic and safety risks represent the best opportunity to achieve these two goals at present. Artificial fullness implants, restrictive devices, intra-oral devices, malabsorption sleeves, and gastric emptying devices--all of which are reversible--are among the variety of solutions designed to meet specific patient needs. Their uptake will be expedited by a growing private-pay market, which will itself be driven by the growing number of bariatric clinics that offer multiple treatment choices, supported by nutritional and monitoring support. The result will be a rapidly expanding, multi-billion dollar global market for obesity management procedures and technologies that will be shaped by ease-of-use and long-term clinical outcomes.
These are among the findings of this new, data-intensive report published by Health Research International and distributed exclusively by Life Science Intelligence. The report provides "must have" econometric market models and analysis of the trends and emerging technologies impacting the global obesity management market through 2018. It covers ten procedure categories and seven major technology markets for five geographies, and it profiles 43 companies innovating within this space. Because many of the technologies lack long-term outcomes, the report forecasts fairly marginal penetration of the total addressable market. Nevertheless, this translates into a projected increase of 21.9% annually through 2018 and several billion dollars in revenues, based on the magnitude of the global obesity epidemic.
EXECUTIVE SUMMARY Report Assumptions Epidemiology of Obesity Therapeutic Approaches Current and Emerging Technologies Procedures Product Markets Procedures and Markets by Geography Summary Exhibit 1: Global Obese Adult Population by Geography, 2012-2018 Summary Exhibit 2: Overview of Major Therapeutic Approaches to the Treatment of Obesity Summary Exhibit 3: Current and Emerging Obesity Management Technologies, 2013 Summary Exhibit 4: Global Obesity Management Procedures by Major Type, 2012-2018 Summary Exhibit 5: Global Market for Obesity Management Technologies, 2012-2018 Summary Exhibit 6: Global Obesity Management Procedures by Geography, 2012-2018 Summary Exhibit 7: Global Market for Obesity Management Technologies by Geography, 2012-2018 1.0 EPIDEMIOLOGY OF OBESITY 1.1 Definitions 1.2 Causes 1.3 Comorbidities 1.3.1 Type 2 Diabetes 1.3.2 Cardiovascular Disease 1.3.3 Cancer 1.3.4 Obstructive Sleep Apnea 1.3.5 Osteoarthritis 1.3.6 Other Comorbidities 1.4 Financial Implications of Obesity 1.5 Global Trends in Obesity 1.5.1 United States 1.5.2 Europe 1.5.3 Asia-Pacific 1.5.4 Latin America 1.5.5 Rest of World Exhibit 1-1: Measurement of Obesity: Body Mass Index Exhibit 1-2: Measurement of Obesity: Waist-to-Hip Ratio Exhibit 1-3: Major Comorbidities Associated with Obesity Exhibit 1-4: Potential Medical Complications of Obesity Exhibit 1-5: Obesity Costs as Share of Total Health Spending in Selected Nations Exhibit 1-6: Trend in Global Obese Population, 2012-2018 Exhibit 1-7: Distribution of U.S. Obesity by State, 2012 Exhibit 1-8: Trend in Obese U.S. Adult Population by Level, 2012-2018 Exhibit 1-9: Differences in Reported Prevalence of Obesity in Selected European Nations, 2008 and 2009 Exhibit 1-10: Trend in Obese European Adult Population, 2012-2018 Exhibit 1-11: Prevalence of Adult Overweight and Obesity in Selected Asia-Pacific Nations, 2008 Exhibit 1-12: Trend in Obese Asia-Pacific Adult Population, 2012-2018 Exhibit 1-13: Prevalence of Overweight and Obesity in Selected Latin American Nations, 2008 Exhibit 1-14: Trend in Obese Latin American Adult Population, 2012-2018 Exhibit 1-15: Distribution of ROW Adult Population by Major Geography, 2012 and 2018 Exhibit 1-16: Prevalence of Adult Overweight and Obesity in Selected Rest of World Nations, 2008 Exhibit 1-17: Trend in Obese Rest of World Adult Population, 2012-2018 2.0 THERAPEUTIC APPROACHES 2.1 Pharmacologic Therapy 2.1.1 Approaches 2.1.2 Approved Drugs and Performance to Date 188.8.131.52 Belviq (lorcaserin) 184.108.40.206 Xenical/Alli (orlistat) 220.127.116.11 Qysmia (phentermine-topiramate) 2.1.3 Pipeline Products and Clinical Experience 18.104.22.168 Tesofensine 22.214.171.124 Oblean (cetilistat) 2.1.4 Implications for Device Markets 2.2 Surgery 2.2.1 Roux-en-Y Gastric Bypass 2.2.2 Vertical Sleeve Gastrectomy 2.2.3 Vertical Banded Gastroplasty 2.2.4 Adjustable Banding Surgery 2.2.5 Laparoscopic Plication Gastroplasty/Gastric Imbrication 2.2.6 Bile Diversion 126.96.36.199 Traditional Bile Diversion 188.8.131.52 Experimental Bile Diversion 2.3 Endoscopic/Endoluminal 2.3.1 Artificial Fullness Implants 2.3.2 Gastric Emptying 2.3.3 Endoscopic/Endoluminal Gastroplasty Technologies 2.3.4 Malabsorption Devices 2.3.5 Endoscopic Gastric Ablation 2.4 Neuromodulation 2.4.1 Vagal Nerve Modulation 2.4.2 Deep Brain Stimulation 2.5 Intra-Oral Technologies 2.6 Gastric Measurement Devices 2.7 Bariatric Stent-Grafting 2.8 Gastric Artery Embolization 2.9 Gastric Botulinum Toxin Injections Exhibit 2-1: Overview of Major Therapeutic Approaches to the Treatment of Obesity Exhibit 2-2: Major Surgical Options for Obesity Management Exhibit 2-3: Roux-en-Y Gastric Bypass Procedure Exhibit 2-4: Vertical Sleeve Gastrectomy Exhibit 2-5: Vertical Banded Gastroplasty Exhibit 2-6: Adjustable Banding Surgery Exhibit 2-7: Laparoscopic Greater Curvature Plication Gastroplasty Exhibit 2-8: Biliary Pancreatic Diversion and Duodenal Switch Exhibit 2-9: Overview of Endoscopic Approaches to Obesity Management Exhibit 2-10: Neuromodulation Approaches to Obesity Management 3.0 COMPANIES AND TECHNOLOGIES 3.1 Allergan (Lap-Band; Orbera) 3.2 Allurion Technologies 3.3 A.M.I. (Soft Gastric Bands) 3.4 Apollo Endosurgery (Overstitch) 3.5 Aspire Bariatrics (AspireAssist) 3.6 Bariatec Corporation (GaBP Ring Autolock) 3.7 Bariatric Solutions GmbH (MiniMizer) 3.8 BAROnova (Transpyloric Shuttle) 3.9 BaroSense (TERIS, ACE Stapler) 3.10 Beta-Stim Ltd. (Balance System) 3.11 BFKW LLC (Full Sense) 3.12 C.R. Bard (EndoCinch; RS2 Restore) 3.13 Cousin Biotech (Bioring) 3.14 Covidien (Endo Stitch) 3.15 Crospon (EndoFLIP) 3.16 EndoGastric Solutions (Stomaphyx) 3.17 EndoSphere (SatiSphere) 3.18 EndoVx 3.19 EnteroMedics (V-Bloc Maestro) 3.20 Fulfillium 3.21 Gastrx Medical 3.22 Gelesis (GelesisMD, SAEF) 3.23 GI Dynamics (EndoBarrier) 3.24 Helioscopie (Heliosphere, Heliogast) 3.25 HourGlass Technologies (TRIM) 3.26 Imperial College of London (i2MOVE Implant) 3.27 IntraPace (abiliti) 3.28 Johnson & Johnson (Swedish/Realize Band, Spiderman) 3.29 Laboratoire Endalis (End Ball) 3.30 Longevity Surgical (LapProx) 3.31 Medical Innovation Development (Midband) 3.32 Medigus Ltd. (SRS System) 3.33 Medtronic Transneuronix (Transcend) 3.34 MetaCure (Diamond Tantalus) 3.35 Metamodix 3.36 NeuroSigma (DBS) 3.37 Obalon Therapeutics (Obalon) 3.38 Olympus (Eagle Claw VII) 3.39 Onciomed (GVS System) 3.40 Ovesco Endoscopy (OTSC System) 3.41 PlenSat (PlenSat Digestable Balloons) 3.42 ReShape Medical (ReShape Duo) 3.43 SafeStitch Medical 3.44 Satiety (TOGA System) 3.45 Scientific Intake (SMART) 3.46 Sensate LLC 3.47 Silhouette Medical (nObese) 3.48 Silimed (SGB) 3.49 Small Bite (Small Bite) 3.50 Spatz FGIA (Spatz3) 3.51 USGI Medical (Incisionless Surgery Platform) 3.52 ValenTx (ValenTx) 3.53 Vibrynt (PREVAIL Implant) Exhibit 3-1: Overview of Obesity Management Technologies, 2013 Exhibit 3-2: Allergan Lap-Band and Orbera Intragastric Balloon Exhibit 3-3: A.M.I. Soft Gastric Band Premium Exhibit 3-4: Apollo Endosurgery OverStitch Exhibit 3-5: Aspire Bariatrics' AspireAssist System Exhibit 3-6: Bariatec Corporation GaBP Ring Autolock System Exhibit 3-7: Bariatric Solutions GmbH MiniMizer Devices Exhibit 3-8: BAROnova Trans Pyloric Shuttle Exhibit 3-9: BaroSense TERIS Implant Exhibit 3-10: Beta-Stim Ltd. Balance System Exhibit 3-11: BFKW LLC Full Sense Device Exhibit 3-12: C.R. Bard EndoCinch Technology Exhibit 3-13: Cousin Biotech Bioring Devices Exhibit 3-14: Covidien Endo Stitch Exhibit 3-15: Crospon EndoFLIP System Exhibit 3-16: EndoGastric Solutions' StomaphyX Device Exhibit 3-17: EndoSphere SatiSphere Duodenal Flow Restrictor Exhibit 3-18: EnteroMedics' Maestro System Exhibit 3-19: GI Dynamics' EndoBarrier Exhibit 3-20: Helioscopie Heliosphere Bag and Heliogast Bands Exhibit 3-21: HourGlass Technologies' TRIM System Exhibit 3-22: IntraPace abiliti System Exhibit 3-23: Ethicon Endo-Surgery Realize/Swedish Adjustable Gastric Band Exhibit 3-24: Laboratoire Endalis End Ball Exhibit 3-25: Longevity Surgical LapProx Technology Exhibit 3-26: Medical Innovation Development Midband Exhibit 3-27: Medigus SRS System Exhibit 3-28: MetaCure Diamond (Tantalus) System Exhibit 3-29: Metamodix' Implant Liner Exhibit 3-30: Obalon Therapeutics' Obalon Capsule Balloon Exhibit 3-31: Olympus Eagle Claw VII Exhibit 3-32: Onciomed GVS (Patent Drawing) Exhibit 3-33: Ovesco Endoscopy OTSC System Exhibit 3-34: PlenSat Digestable Balloons Exhibit 3-35: ReShape Medical ReShape Duo Exhibit 3-36: SafeStitch Medical Endolumenal Gastroplasty Device Exhibit 3-37: Satiety TOGA System and Procedure Exhibit 3-38: Silimed Gastric Balloon (SGB) Exhibit 3-39: Small Bite Device Exhibit 3-40: Spatz FGIA Spatz3 Adjustable Balloon System Exhibit 3-41: USGI Medical Incisionless Surgery Platform Exhibit 3-42: ValenTx Endoluminal Bypass Technology Exhibit 3-43: Vibrynt PREVAIL System 4.0 PROCEDURE FORECASTS 4.1 Roux-en-Y Gastric Bypass Surgery 4.2 Sleeve Gastrectomy 4.3 Adjustable Gastric Banding 4.4 Artificial Fullness Device Implantations 4.5 Oral Hydrogel Product Patients 4.6 Endoluminal Bariatric Surgery 4.7 Malabsorption Device Implantations 4.8 Gastric Emptying Device Implantations 4.9 Intra-Oral Device Implantations 4.10 Neuromodulation Device Implantations Exhibit 4-1: Global Obesity Management Procedures by Major Type, 2012-2018 Exhibit 4-2: Roux-en-Y Gastric Bypass Surgery, Procedure Forecast by Region, 2012-2018 Exhibit 4-3: Sleeve Gastrectomy, Procedure Forecast by Region, 2012-2018 Exhibit 4-4: Adjustable Gastric Banding, Procedure Forecast by Region, 2012-2018 Exhibit 4-5: Artificial Fullness Device Implantations, Procedure Forecast by Region, 2012-2018 Exhibit 4-6: Hydrogel Particle Products, Patient Forecast by Region, 2012-2018 Exhibit 4-7: Endoluminal Bariatric Surgery, Procedure Forecast by Region, 2012-2018 Exhibit 4-8: Malabsorption Device Implantations, Procedure Forecast by Region, 2012-2018 Exhibit 4-9: Gastric Emptying Device Implantations, Procedure Forecast by Region, 2012-2018 Exhibit 4-10: Intra-Oral Device Implantations, Procedure Forecast by Region, 2012-2018 Exhibit 4-11: Neuromodulation Device Implantations, Procedure Forecast by Region, 2012-2018 5.0 PRODUCT MARKETS 5.1 Restrictive Devices 5.2 Artificial Fullness Devices 5.2.1 AFD Implants 5.2.2 Oral Hydrogel Particle Products 5.3 Endo Surgery Devices 5.4 Malabsorption Devices 5.5 Gastric Emptying Devices 5.6 Intra-Oral Devices 5.7 Neuromodulation Devices Exhibit 5-1: Obesity Management Technologies, Global Market Forecast by Type, 2012-2018 Exhibit 5-2: Restrictive Devices, Global Market Forecast by Geography, 2012-2018 Exhibit 5-3: Artificial Fullness Devices, Market Forecast by Major Type, 2012-2018 Exhibit 5-4: Artificial Fullness Devices, Global Market Forecast by Geography, 2012-2018 Exhibit 5-5: Oral Hydrogel Particles, Global Market Forecast by Geography, 2012-2018 Exhibit 5-6: Endo Surgery Devices, Global Market Forecast by Geography, 2012-2018 Exhibit 5-7: Malabsorption Devices, Global Market Forecast by Geography, 2012-2018 Exhibit 5-8: Gastric Emptying Devices, Global Market Forecast by Geography, 2012-2018 Exhibit 5-9: Intra-Oral Devices, Global Market Forecast by Geography, 2012-2018 Exhibit 5-10: Neuromodulation Devices, Global Market Forecast by Geography, 2012-2018 6.0 PROCEDURES & MARKETS BY GEOGRAPHY 6.1 United States 6.2 Europe 6.3 Asia-Pacific 6.4 Latin America 6.5 Rest of World Exhibit 6-1: Global Obesity Management Procedures by Geography, 2012-2018 Exhibit 6-2: Global Market for Obesity Management Technologies by Geography, 2012-2018 Exhibit 6-3: U.S. Obesity Management Procedures by Type, 2012-2018 Exhibit 6-4: U.S. Market for Obesity Management Technologies by Major Type, 2012-2018 Exhibit 6-5: Europe Obesity Management Procedures by Type, 2012-2018 Exhibit 6-6: Europe Market for Obesity Management Technologies by Major Type, 2012-2018 Exhibit 6-7: Asia-Pacific Obesity Management Procedures by Type, 2012-2018 Exhibit 6-8: Asia-Pacific Market for Obesity Management Technologies by Major Type, 2012-2018 Exhibit 6-9: Latin America Obesity Management Procedures by Type, 2012-2018 Exhibit 6-10: Latin America Market for Obesity Management Technologies by Major Type, 2012-2018 Exhibit 6-11: Rest of World Obesity Management Procedures by Type, 2012-2018 Exhibit 6-12: Rest of World Market for Obesity Management Technologies by Major Type, 2012-2018