U.S. DISEASE INCIDENCE AND PREVALENCE

380 Pages | 122 Exhibits | 2014 Analysis

OVERVIEW:
This comprehensive report examines the etiology and epidemiology, number of hospital discharges, incidence and prevalence, and mortality rates of the most prevalent diseases/disorders in the United States for the years 2000-2010, and 2013. Categories covered by this report include:
  • Blood disorders (anemia and hemophilia);
  • Cancer (breast, colon/rectum, lung, nervous system, ovaries, pancreas, prostate, and skin);
  • Cardiovascular diseases/disorders (atherosclerosis, heart failure, high blood pressure, high cholesterol, metabolic syndrome, pacing disorders, and valvular heart disease);
  • Gastric and metabolic diseases/disorders (diabetes, gastroesophageal reflux disease, irritable bowel syndrome, kidney disease, and obesity);
  • Musculoskeletal diseases/disorders (arthritis, carpal tunnel syndrome, muscular dystrophy, and osteoporosis);
  • Neurologic and psychiatric diseases/disorders (Alzheimer's disease, amyotrophic lateral disease, depression, epilepsy, multiple sclerosis, Parkinson's disease, schizophrenia, and stroke);
  • Ophthalmic diseases/disorders (cataracts and glaucoma);
  • Reproductive and genitourinary disorders (benign prostatic hyperplasia, erectile dysfunction, infertility, and urinary incontinence);
  • Respiratory diseases/disorders (apnea, asthma, chronic obstructive pulmonary disease, cystic fibrosis, emphysema, pneumonia, respiratory failure, and tuberculosis);
  • Sexually transmitted diseases (genital herpes, human papillomavirus, and human immunodeficiency virus/acquired immune deficiency syndrome); and,
  • Skin wounds (diabetic and pressure ulcers, surgical wounds, and traumatic wounds).


TABLE OF CONTENTS:
INTRODUCTION 

1. BLOOD DISORDERS
 
1.1 Anemia 
	1.1.1 Iron Deficiency Anemia 
		1.1.1.1 Etiology 
		1.1.1.2 Epidemiology 
	1.1.2 Sickle Cell Anemia 
		1.1.2.1 Etiology 
		1.1.2.2 Epidemiology 
	1.1.3 Thalassemia 
		1.1.3.1 Etiology 
		1.1.3.2 Epidemiology 
1.2 Hemophilia 
	1.2.1 Etiology
	1.2.2 Epidemiology
 
Exhibit 1-1: Iron Deficiency Anemia, Facts and Figures 
Exhibit 1-2: Sickle Cell Anemia, Facts and Figures 
Exhibit 1-3: Thalassemia, Facts and Figures 
Exhibit 1-4: Hemophilia, Facts and Figures 
Exhibit 1-5: Hemophilia, Selected Demographic Characteristics
 
2. CANCER
 
2.1 Incidence and Prevalence 
	2.1.1 Mortality Rate 
	2.1.2 The Cost of Cancer 
2.2 Cancer Types 
	2.2.1 Bladder Cancer 
		2.2.1.1 Etiology 
		2.2.1.2 Epidemiology 
	2.2.2 Breast Cancer 
		2.2.2.1 Etiology 
		2.2.2.2 Epidemiology 
	2.2.3 Bronchial/Lung Cancer 
		2.2.3.1 Etiology 
		2.2.3.2 Epidemiology 
	2.2.4 Cervical/Uterine Cancer 
		2.2.4.1 Etiology 
		2.2.4.2 Epidemiology 
	2.2.5 Colorectal Cancer 
		2.2.5.1 Etiology 
		2.2.5.2 Epidemiology 
	2.2.6 Leukemia 
		2.2.6.1 Etiology 
		2.2.6.2 Epidemiology 
	2.2.7 Lymphoma 
		2.2.7.1 Etiology 
		2.2.7.2 Epidemiology 
	2.2.8 Brain/Nervous System Cancer 
		2.2.8.1 Etiology 
		2.2.8.2 Epidemiology 
	2.2.9 Oral Cancer 
		2.2.9.1 Etiology 
		2.2.9.2 Epidemiology 
	2.2.10 Ovarian Cancer 
		2.2.10.1 Etiology
		2.2.10.2 Epidemiology 
	2.2.11 Pancreatic Cancer 
		2.2.11.1 Etiology 
		2.2.11.2 Epidemiology 
	2.2.12 Prostate Cancer 
		2.2.12.1 Etiology 
		2.2.12.2 Epidemiology 
	2.2.13 Skin Cancer 
		2.2.13.1 Etiology 
		2.2.13.2 Epidemiology 

Exhibit 2-1: Cancer Incidence, by Anatomic Site, 2014 
Exhibit 2-2: Hospital Discharge Statistics for Selected Cancers, by Anatomic Site, 2000-2010 
Exhibit 2-3: Cancer Prevalence, by Anatomic Site and Gender, 2011 
Exhibit 2-4: Bladder Cancer, Facts and Figures 
Exhibit 2-5: Breast Cancer, Facts and Figures 
Exhibit 2-6: Bronchial/Lung Cancer, Facts and Figures 
Exhibit 2-7: Cervical Cancer, Facts and Figures 
Exhibit 2-8: Uterine Cancer, Facts and Figures 
Exhibit 2-9: Colorectal Cancer, Facts and Figures 
Exhibit 2-10: Leukemia, Facts and Figures
Exhibit 2-11: Leukemia Incidence, by Type and Gender 
Exhibit 2-12: Non-Hodgkin Lymphoma, Facts and Figures 
Exhibit 2-13: Hodgkin Lymphoma, Facts and Figures 
Exhibit 2-14: Brain/Nervous System Cancer, Facts and Figures 
Exhibit 2-15: Oral Cancer, Facts and Figures 
Exhibit 2-16: Ovarian Cancer, Facts and Figures 
Exhibit 2-17: Pancreatic Cancer, Facts and Figures 
Exhibit 2-18: Prostate Cancer, Facts and Figures 
Exhibit 2-19: Melanoma, Facts and Figures
 
3. CARDIOVASCULAR DISEASES/DISORDERS
 
3.1 Atherosclerosis 
	3.1.1 Coronary Atherosclerosis 
		3.1.1.1 Etiology 
		3.1.1.2 Epidemiology 
	3.1.2 Peripheral Artery Disease 
		3.1.2.1 Etiology 
		3.1.2.2 Epidemiology 
3.2 Heart Failure
	3.2.1 Etiology
	3.2.2 Epidemiology 
3.3 Hypercholesterolemia 
	3.3.1 Etiology
	3.3.2 Epidemiology 
3.4 Hypertension 
	3.4.1 Etiology
	3.4.2 Epidemiology 
3.5 Ischemic Heart Disease 
	3.5.1 Angina Pectoris 
		3.5.1.1 Etiology 
		3.5.1.2 Epidemiology 
	3.5.2 Myocardial Infarction 
		3.5.2.1 Etiology 
		3.5.2.2 Epidemiology 
3.6 Metabolic Syndrome 
	3.6.1 Etiology
	3.6.2 Epidemiology 
3.7 Pacing Disorders 
	3.7.1 Arrhythmia 
		3.7.1.1 Etiology 
		3.7.1.2 Epidemiology 
	3.7.2 Sudden Cardiac Death 
		3.7.2.1 Etiology 
		3.7.2.2 Epidemiology 
3.8 Valvular Heart Disease 
	3.8.1 Etiology
	3.8.2 Epidemiology
 
Exhibit 3-1: Coronary Atherosclerosis, Facts and Figures 
Exhibit 3-2: Peripheral Artery Disease, Facts and Figures 
Exhibit 3-3: Heart Failure, Facts and Figures 
Exhibit 3-4: Hypercholesterolemia, Facts and Figures 
Exhibit 3-5: Hypertension, Facts and Figures 
Exhibit 3-6: Angina Pectoris, Facts and Figures 
Exhibit 3-7: Myocardial Infarction, Facts and Figures 
Exhibit 3-8: Metabolic Syndrome, Facts and Figures 
Exhibit 3-9: Arrhythmia, Facts and Figures 
Exhibit 3-10: Tachycardia, Facts and Figures 
Exhibit 3-11: Sudden Cardiac Death, Facts and Figures 
Exhibit 3-12: Valvular Heart Disease, Facts and Figures 

4. GASTRIC AND METABOLIC DISEASES/DISORDERS
 
4.1 Cholelithiasis 
	4.1.1 Etiology
	4.1.2 Epidemiology 
4.2 Chronic Kidney Disease 
	4.2.1 Etiology
	4.2.2 Epidemiology 
4.3 Crohn's Disease 
	4.3.1 Etiology 
	4.3.2 Epidemiology 
4.4 Diabetes 
	4.4.1 Etiology 
	4.4.2 Epidemiology
4.5 End-Stage Renal Disease 
	4.5.1 Etiology 
	4.5.2 Epidemiology 
4.6 Gastroesophageal Reflux Disease 
	4.6.1 Etiology 
	4.6.2 Epidemiology 
4.7 Irritable Bowel Syndrome 
	4.7.1 Etiology 
	4.7.2 Epidemiology 
4.8 Obesity 
	4.8.1 Etiology 
	4.8.2 Epidemiology 
4.9 Urolithiasis 
	4.9.1 Etiology 
	4.9.2 Epidemiology 

Exhibit 4-1: Cholelithiasis, Facts and Figures
Exhibit 4-2: Chronic Kidney Disease, Facts and Figures 
Exhibit 4-3: Crohn's Disease, Facts and Figures 
Exhibit 4-4: Diabetes, Facts and Figures 
Exhibit 4-5: 2013, Prevalence of Diabetes, by Age and Gender
Exhibit 4-6: End-Stage Renal Disease, Facts and Figures 
Exhibit 4-7: Gastroesophageal Reflux Disease, Facts and Figures 
Exhibit 4-8: Irritable Bowel Syndrome, Facts and Figures 
Exhibit 4-9: Possible Causes for Irritable Bowel Syndrome 
Exhibit 4-10: Body Mass Index Ranges for Adults 
Exhibit 4-11: Obesity, Facts and Figures 
Exhibit 4-12: Urolithiasis, Facts and Figures 
Exhibit 4-13: Selected Predisposing Factors for Developing Kidney Stones 

5. MUSCULOSKELETAL DISEASES/DISORDERS
 
5.1 Arthritis 
	5.1.1 Osteoarthritis 
		5.1.1.1 Etiology 
		5.1.1.2 Epidemiology 
	5.1.2 Rheumatoid Arthritis 
		5.1.2.1 Etiology 
		5.1.2.2 Epidemiology 
5.2 Carpal Tunnel Syndrome 
	5.2.1 Etiology 
	5.2.2 Epidemiology 
5.3 Duchenne Muscular Dystrophy
	5.3.1 Etiology 
	5.3.2 Epidemiology 
5.4 Osteoporosis 
	5.4.1 Etiology 
	5.4.2 Epidemiology 

Exhibit 5-1: Prevalence of Arthritis, in 5-Year Intervals, 2005-2030 
Exhibit 5-2: Osteoarthritis, Facts and Figures 
Exhibit 5-3: Rheumatoid Arthritis, Facts and Figures 
Exhibit 5-4: Carpal Tunnel Syndrome, Facts and Figures 
Exhibit 5-5: Carpal Tunnel Syndrome, Cases Resulting in Time Away from Work, 2000-2012 
Exhibit 5-6: Duchenne Muscular Dystrophy, Facts and Figures 
Exhibit 5-7: Incidence of Osteoporosis-Related Fractures, by Site .
Exhibit 5-8: Osteoporosis, Facts and Figures 
Exhibit 5-9: Number of Persons with Osteoporosis and Osteopenia, by Selected States, 2010 and 2030 

6. NEUROLOGIC AND PSYCHIATRIC DISEASES/DISORDERS
 
6.1 Alzheimer's Disease 
	6.1.1 Etiology 
	6.1.2 Epidemiology 
6.2 Amyotrophic Lateral Sclerosis
	6.2.1 Etiology 
	6.2.2 Epidemiology 
6.3 Cerebrovascular Diseases/Disorders
	6.3.1 Arteriovenous Malformation 
		6.3.1.1 Etiology 
		6.3.1.2 Epidemiology
	6.3.2 Cerebral Aneurysm
		6.3.2.1 Etiology 
		6.3.2.2 Epidemiology 
	6.3.3 Stroke
		6.3.3.1 Etiology 
		6.3.3.2 Epidemiology 
6.4 Epilepsy 
	6.4.1 Etiology 
	6.4.2 Epidemiology 
6.5 Huntington's Disease 
	6.5.1 Etiology 
	6.5.2 Epidemiology 
6.6 Hydrocephalus
	6.6.1 Etiology 
	6.6.2 Epidemiology 
6.7 Multiple Sclerosis 
	6.7.1 Etiology 
	6.7.2 Epidemiology 
6.8 Myasthenia Gravis 
	6.8.1 Etiology 
	6.8.2 Epidemiology 
6.9 Parkinson's Disease 
	6.9.1 Etiology 
	6.9.2 Epidemiology 
6.10 Psychiatric Disorders 
	6.10.1 Attention Deficient Hyperactivity Disorder 
		6.10.1.1 Etiology 
		6.10.1.2 Epidemiology 
	6.10.2 Bipolar Disorder 
		6.10.2.1 Etiology 
		6.10.2.2 Epidemiology 
	6.10.3 Depression 
		6.10.3.1 Etiology 
		6.10.3.2 Epidemiology 
	6.10.4 Schizophrenia 
		6.10.4.1 Etiology 
		6.10.4.2 Epidemiology 

Exhibit 6-1: Alzheimer's Disease, Facts and Figures 
Exhibit 6-2: Amyotrophic Lateral Sclerosis, Facts and Figures
Exhibit 6-3: Arteriovenous Malformation, Facts and Figures 
Exhibit 6-4: Cerebral Aneurysm, Facts and Figures 
Exhibit 6-5: Stroke, Facts and Figures 
Exhibit 6-6: Epilepsy, Facts and Figures 
Exhibit 6-7: Huntington's Disease, Facts and Figures 
Exhibit 6-8: Hydrocephalus, Facts and Figures 
Exhibit 6-9: Multiple Sclerosis, Facts and Figures 
Exhibit 6-10: Myasthenia Gravis, Facts and Figures 
Exhibit 6-11: Parkinson's Disease, Facts and Figures 
Exhibit 6-12: Percentage of Adults Experiencing Serious Psychological Distress, by Age and Gender 
Exhibit 6-13: Attention Deficit Hyperactivity Disorder, Facts and Figures 
Exhibit 6-14: Bipolar Disorder, Facts and Figures 
Exhibit 6-15: Depression, Facts and Figures 
Exhibit 6-16: Schizophrenia, Facts and Figures 

7. OPHTHALMIC DISEASES/DISORDERS
 
7.1 Cataracts 
	7.1.1 Etiology 
	7.1.2 Epidemiology 
7.2 Glaucoma 
	7.2.1 Etiology 
	7.2.2 Epidemiology 

Exhibit 7-1: Cataracts, Facts and Figures 
Exhibit 7-2: 2010, Prevalence of Cataracts, by Age 
Exhibit 7-3: Glaucoma, Facts and Figures
Exhibit 7-4: New Discoveries for the Cause of Vision Loss in Glaucoma 
Exhibit 7-5: 2010, Prevalence of Glaucoma, by Age 

8. REPRODUCTIVE AND GENITOURINARY DISORDERS
 
8.1 Female Reproductive Disorders 
	8.1.1 Endometriosis 
		8.1.1.1 Etiology 
		8.1.1.2 Epidemiology 
	8.1.2 Infertility 
		8.1.2.1 Etiology 
		8.1.2.2 Epidemiology 
8.2 Male Reproductive Disorders 
	8.2.1 Benign Prostatic Hyperplasia 
		8.2.1.1 Etiology 
		8.2.1.2 Epidemiology 
	8.2.2 Erectile Dysfunction 
		8.2.2.1 Etiology 
		8.2.2.2 Epidemiology 
	8.2.3 Infertility 
		8.2.3.1 Etiology 
		8.2.3.2 Epidemiology 
8.3 Urinary Incontinence 
	8.3.1 Etiology 
	8.3.2 Epidemiology 

Exhibit 8-1: Endometriosis, Facts and Figures 
Exhibit 8-2: Female Infertility, Facts and Figures 
Exhibit 8-3: Benign Prostatic Hyperplasia, Facts and Figures 
Exhibit 8-4: Erectile Dysfunction, Facts and Figures 
Exhibit 8-5: Male Infertility, Facts and Figures 
Exhibit 8-6: Types of Urinary Incontinence 
Exhibit 8-7: Urinary Incontinence, Facts and Figures 

9. RESPIRATORY DISEASES/DISORDERS
 
9.1 Acute Respiratory Distress Syndrome 
	9.1.1 Etiology
	9.1.2 Epidemiology 
9.2 Apnea 
	9.2.1 Sleep Apnea 
		9.2.1.1 Etiology 
		9.2.1.2 Epidemiology 
	9.2.2 Sudden Infant Death Syndrome 
		9.2.2.1 Etiology 
		9.2.2.2 Epidemiology 
9.3 Asthma 
	9.3.1 Etiology 
	9.3.2 Epidemiology 
9.4 Chronic Obstructive Pulmonary Disease 
	9.4.1 Chronic Bronchitis 
		9.4.1.1 Etiology 
		9.4.1.2 Epidemiology 
	9.4.2 Emphysema  
		9.4.2.1 Etiology 
		9.4.2.2 Epidemiology
9.5 Cystic Fibrosis 
	9.5.1 Etiology 
	9.5.2 Epidemiology 
9.6 Infectious Diseases 
	9.6.1 Pneumonia 
		9.6.1.1 Etiology 
		9.6.1.2 Epidemiology 
	9.6.2 Tuberculosis 
		9.6.2.1 Etiology 
		9.6.2.2 Epidemiology 
9.7 Pleural Disorders 
	9.7.1 Empyema 
		9.7.1.1 Etiology 
		9.7.1.2 Epidemiology 
	9.7.2 Pleural Effusion 
		9.7.2.1 Etiology 
		9.7.2.2 Epidemiology
	9.7.3 Pneumothorax 
		9.7.3.1 Etiology 
		9.7.3.2 Epidemiology 
9.8 Pulmonary Embolism 
	9.8.1 Etiology 
	9.8.2 Epidemiology 
9.9 Respiratory Failure 
	9.9.1 Etiology 
	9.9.2 Epidemiology 
9.10 Restrictive Lung Disease 
	9.10.1 Etiology 
	9.10.2 Epidemiology 

Exhibit 9-1: Adult Respiratory Distress Syndrome, Facts and Figures 
Exhibit 9-2: Sleep Apnea, Facts and Figures 
Exhibit 9-3: Sudden Infant Death Syndrome, Facts and Figures 
Exhibit 9-4: Asthma, Facts and Figures 
Exhibit 9-5: 2013, Prevalence of Asthma, by Age, Ethnicity, and Gender 
Exhibit 9-6: Chronic Bronchitis, Facts and Figures 
Exhibit 9-7: Emphysema, Facts and Figures 
Exhibit 9-8: Cystic Fibrosis, Facts and Figures 
Exhibit 9-9: Pneumonia, Facts and Figures 
Exhibit 9-10: Tuberculosis, Facts and Figures
Exhibit 9-11: Tuberculosis Cases in the United States, 1993-2012 
Exhibit 9-12: 2012, Tuberculosis Cases, by Ethnicity 
Exhibit 9-13: Pleural Disorders, Facts and Figures 
Exhibit 9-14: Pulmonary Embolism, Facts and Figures 
Exhibit 9-15: Respiratory Failure, Facts and Figures 
Exhibit 9-16: Restrictive Lung Disease, Facts and Figures 

10. SEXUALLY TRANSMITTED DISEASES
 
10.1. Genital Herpes
	10.1.1 Etiology 
	10.1.2 Epidemiology 
10.2 Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome 
	10.2.1 Etiology 
	10.2.2 Disease Progression 
	10.2.3 Epidemiology 
10.3 Human Papillomavirus 
	10.3.1 Etiology 
	10.3.2 Epidemiology 

Exhibit 10-1: Genital Herpes, Facts and Figures 
Exhibit 10-2: Physician Office Visits for Genital Herpes, 1999-2012 
Exhibit 10-3: Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, Facts and Figures 
Exhibit 10-4: Acquired Immune Deficiency Syndrome, Indicator/Opportunistic Diseases 
Exhibit 10-5: Incidence and Cumulative Prevalence of Acquired Immune Deficiency Syndrome in the United States, by Age, Ethnicity, Gender, and Region, 2008-2011 
Exhibit 10-6: Prevalence of Acquired Immune Deficiency Syndrome in the United States, by Age, Ethnicity, Gender, and Region, 2008-2010
Exhibit 10-7: Deaths Due to Acquired Immune Deficiency Syndrome, by Age, Ethnicity, Gender, and Region, 2008-2010 
Exhibit 10-8: 2013, Percentage of Adults Tested for Human Immunodeficiency Virus, by Age and Gender 
Exhibit 10-9: 2013, Number of Adults Tested for Human Immunodeficiency Virus, by Age, Gender, and Ethnicity 
Exhibit 10-10: Human Papillomavirus, Facts and Figures 

11. SKIN WOUNDS

11.1 Factors Affecting Wound Closure 
	11.1.1 Intrinsic Factors
		11.1.1.1 Age and Chronic Illness 
		11.1.1.2 Body Composition 
		11.1.1.3 Nutritional Status 
	11.1.2 Extrinsic Factors 
		11.1.2.1 Ambient Temperature 
		11.1.2.2 Desiccation/Hydration 
		11.1.2.3 Infection 
		11.1.2.4 Maceration
		11.1.2.5 Medications and Other Treatment Modalities 
		11.1.2.6 Necrotic Tissue and Debris 
		11.1.2.7 Oxygen 
		11.1.2.8 Stress 
		11.1.2.9 Wound Creation and Depth 
		11.1.2.10 Wound Closure Techniques 
		11.1.2.11 Other Extrinsic Factors 
	11.1.3 Complications of Wound Healing 
		11.1.3.1 Scarring 
		11.1.3.2 Bleeding 
11.2 Wound Types 
	11.2.1 Illness-Related Wounds 
		11.2.1.1 Etiology 
			11.2.1.1.1 Arterial Ulcers 
			11.2.1.1.2 Diabetic Ulcers 
			11.2.1.1.3 Venous Ulcers 
		11.2.1.2 Epidemiology 
	11.2.2 Pressure Ulcers 
		11.2.2.1 Etiology 
		11.2.2.2 Epidemiology 
	11.2.3 Surgical Wounds 
		11.2.3.1 Etiology 
		11.2.3.2 Epidemiology 
	11.2.4 Traumatic Wounds 
		11.2.4.1 Etiology 
			11.2.4.1.1 Abrasions, Contusions, and Lacerations 
			11.2.4.1.2 Amputations 
			11.2.4.1.3 Burns 
		11.2.4.2 Epidemiology 

Exhibit 11-1: Intrinsic and Extrinsic Factors Affecting Wound Closure 
Exhibit 11-2: Illness-Related Wounds, Facts and Figures 
Exhibit 11-3: Pressure Ulcers, Facts and Figures
Exhibit 11-4: Stages of Pressure Ulcers 
Exhibit 11-5: Surgical Wounds, Facts and Figures 
Exhibit 11-6: Lacerations and Other Types of Traumatic Wounds, Facts and Figures 
Exhibit 11-7: Amputations, Facts and Figures 
Exhibit 11-8: Burns, Facts and Figures 
Exhibit 11-9: Classification of Burns, by Mechanism of Injury 
Exhibit 11-10: Stages of Burn Wounds 



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