This report will cover:
• Emerging and existing cellular therapies for hard and soft musculoskeletal tissue repair and regeneration;
• Key factors influencing the growth of individual product markets;
• Estimated market shares and sales among major U.S. suppliers
• Companies and biotech firms developing novel cellular therapies; and,
• Major supplier product portfolio analysis in individual product markets.
The scope of the analysis of this report covers companies developing and distributing biologics and novel cellular therapeutics for the treatment of musculoskeletal injuries. Hard tissue musculoskeletal products covered in this report include bone allograft and machined bone, demineralized bone matrix, growth factor-based bone grafts, cellular bone matrices, and select other biologics. Soft tissue musculoskeletal products covered by this report include cartilage regeneration and repair products, ligament and tendon repair technologies, and meniscus repair and regeneration products.
EXECUTIVE SUMMARY i. Methodology Exhibit ES-1: 2014, U.S. Orthopedic Biologic and Tissue Engineered Products Market, Share by Products 1. OVERVIEW OF MUSCULOSKELETAL DISEASES/DISORDERS 1.1 Back Pain and Spine Surgery 1.2 Carpal Tunnel Syndrome 1.3 Duchenne Muscular Dystrophy 1.4 Osteoarthritis 1.5 Osteoporosis and Fractures 1.6 Rheumatoid Arthritis Exhibit 1-1: Musculoskeletal Surgery, Procedure Volumes Forecast, by Type, 2014-2019 2. U.S. MARKETS FOR BIOLOGIC MUSCULOSKELETAL SOFT TISSUE REGENERATION AND REPAIR PRODUCTS 2.1 Cartilage Regeneration and Repair Technologies 2.1.1 Currently Available Products 22.214.171.124 Arthrex 126.96.36.199 Vericel 188.8.131.52 Zimmer 2.1.2 Products in Development 184.108.40.206 CellCoTec 220.127.116.11 Cytori Therapeutics 18.104.22.168 Histogenics 22.214.171.124 ISTO Technologies 126.96.36.199 Medipost 188.8.131.52 TETEC 184.108.40.206 TiGenix 220.127.116.11 TissueGene 2.1.3 Market Forecast 2.1.4 Competitive Analysis 2.2 Ligament and Tendon Repair Technologies 2.2.1 Graft-Based Products Overview 2.2.2 Tissue Engineering 18.104.22.168 Biologic Scaffolds 22.214.171.124 Developmental Biologic Scaffolds 2.2.3 Market Forecast 2.2.4 Competitive Analysis 2.3 Meniscus Repair and Regeneration Technologies 2.3.1 Products Overview 2.3.2 Market Forecast 2.3.3 Competitive Analysis 2.2.4 U.S. Markets for Biologic Soft Tissue Regeneration and Repair Products Exhibit 2-1: 2014, Cartilage Repair Procedures Exhibit 2-2: Cartilage Repair and Regeneration Products, Market Forecast, 2014-2019 Exhibit 2-3: 2014, Knee Cartilage Repair and Regeneration Products Market, Share by Supplier Exhibit 2-4: 2015, Selected Allografts for Ligament and Tendon Replacement Exhibit 2-5: 2015, Biologic Scaffolds and Matrices for Ligament and Tendon Repair Exhibit 2-6: Ligament and Tendon Replacement and Regeneration Products, Market Forecast, 2014-2019 Exhibit 2-7: 2014, Ligament and Tendon Replacement and Regeneration Products Market, Share by Supplier Exhibit 2-8: 2015, Selected Biologic Meniscal Repair Products Exhibit 2-9: Meniscal Replacement and Regeneration Products, Market Forecast, 2014-2019 Exhibit 2-10: 2014, Meniscal Replacement and Regeneration Products Market, Share by Supplier Exhibit 2-11: Musculoskeletal Soft Tissue Biologics Products, Market Forecast, 2014-2019 3. U.S. MARKETS FOR BIOLOGIC MUSCULOSKELETAL HARD TISSUE REGENERATION AND REPAIR 3.1 Bone Graft and Bone Substitute Products on the Market and Under Development 3.1.1 Bone Autograft 3.1.2 Bone Allografts and Machined Bone 3.1.3 Demineralized Bone Matrix 3.1.4 Market Forecast 3.1.5 Competitive Analysis 3.2 Growth Factor-Based Bone Grafts 3.2.1 Products Overview 126.96.36.199 Bioventus 188.8.131.52 Medtronic 184.108.40.206 Wright Medical Technology 3.2.2 Market Forecast 3.2.3 Competitive Analysis 3.3 Other Biologics Currently Available or in Development 3.3.1 Cellular Bone Matrices 220.127.116.11 AlloSource 18.104.22.168 Biomet 22.214.171.124 NuVasive 126.96.36.199 Orthofix 188.8.131.52 Osiris Therapeutics 184.108.40.206 RTI Surgical 3.3.2 Cellular Regeneration Therapies in Development for Hard Bone Musculoskeletal Repair 220.127.116.11 Cerapedics, Inc. 18.104.22.168 Ferring Pharmaceuticals 22.214.171.124 Mesoblast 3.3.3 Market Forecast 3.3.4 Competitive Analysis 3.4 Emerging Areas of Cellular Therapy for Soft and Hard Tissue Repair and Regeneration 3.4.1 Bone Marrow Aspirate Concentrate 3.4.2 Gene Therapy 126.96.36.199 Systemic Gene Therapy 188.8.131.52 Regional Gene Therapy 3.4.3 Three-Dimensional Printing 3.5 U.S. Markets for Musculoskeletal Hard Tissue Regeneration and Repair Products 3.6 Combined Market Summary for Hard and Soft Tissue Engineering and Cellular Therapy Products Exhibit 3-1: 2015, Description and Representative Pricing of Base Allografts Used in Spine Surgery Exhibit 3-2: 2015, Selected Bone Allograft and Machined Bone Products Exhibit 3-3: 2015, Selected Demineralized Bone Matrix Products Exhibit 3-4: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2014-2019 Exhibit 3-5: 2014, Bone Allograft Products Market, Share by Supplier Exhibit 3-6: 2014, Demineralized Bone Matrix Products Market, Share by Supplier Exhibit 3-7: Growth Factor-Based Products, Market Forecast, 2014-2019 Exhibit 3-8: 2014, Growth Factor-Based Products Market, Share by Supplier Exhibit 3-9: Stem Cell Matrices and Other Osteobiologic Agents for Bone Healing and Enhancement of Spinal Fusion, Market Forecast, 2014-2019 Exhibit 3-10: 2014, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion by Application Exhibit 3-11: 2014, Stem Cell Products and Other Orthobiologics for Bone Healing and Spinal Fusion, Share by Supplier Exhibit 3-12: U.S. Biologic Products for Musculoskeletal Hard Tissue Repair and Regeneration, Combined Market Forecast, 2014-2019 Exhibit 3-13: U.S. Hard and Soft Musculoskeletal Tissue Repair and Regeneration, Combined Procedure Volumes, 2014-2019 Exhibit 3-14: U.S. Biologic Products for Musculoskeletal Hard and Soft Tissue Repair and Regeneration, Combined Market Forecast, 2014-2019 APPENDIX: COMPANY LISTING BIBLIOGRAPHY