GLOBAL SPINAL IMPLANTS MARKET

223 Pages | 51 Exhibits | 2015 Analysis | Forecasts Through 2020 Product Family: Market Reports




OVERVIEW:
Spine disorders are a leading driver of healthcare costs worldwide, and range in severity from mild pain and loss of feeling to extreme pain and paralysis. These disorders are primarily caused by degenerative conditions in the spine, deformity, tumors and trauma. Degenerative disc disease (DDD) typically is caused by gradual disc damage and often results in disc herniation and chronic back or neck pain; the disease is most common among otherwise healthy people in their 30s or 40s and affects approximately half of the population in the 7 major markets aged 40 and older.

This report provides a summary of the nearly $5 billion global spinal implants market, which (for the purposes of this report) includes the following selected product segments in the top 5 markets of the European Union (France, Germany, Italy, Spain, the U.K.), as well as Japan and the U.S.:

  1. Artificial cervical and lumbar discs;
  2. Dynamic stabilization devices (interspinous process spacers and pedicle screw-based dynamic stabilization devices);
  3. Other motion preserving devices (annulus repair);
  4. Spinal fusion instrumentation (anterior cervical plates, interbody fusion devices and pedicle screws); and,
  5. Vertebral compression fracture treatments (balloon kyphoplasty/percutaneous vertebral augmentation systems and vertebroplasty products).
The largest segment-spinal fusion instrumentation-comprised the vast majority of sales, at approximately 57.4% of the total market, followed by dynamic stabilization devices (18.8%), vertebral compression fraction treatment products (14.4%), artificial cervical/lumbar discs (9.3%), and the very small but emerging market of annulus repair products (at less than 1%). Overall, this large and burgeoning market is growing at a better-than-average compound annual rate of nearly 5%.

This dynamic, new report from Medtech Insight includes a profile of dozens of selected leading products; clinical study results; a comprehensive market analysis, including expected segment growth, drivers/limiters, and market forecasts (from 2015-2020); and competitive analysis, including estimated 2015 market share by supplier. Emerging technologies (cell-based therapies, tissue engineering products and biologics) are also profiled.

TABLE OF CONTENTS:
EXECUTIVE SUMMARY
 
i. Global Spinal Implants Market 
ii. Methodology 

Exhibit ES-1: Global Spinal Implants Market, Combined Sales, 2015-2020 
Exhibit ES-2: 2015, Global Spinal Implants Market, Share by Segment 

1. CLINICAL OVERVIEW
 
1.1 Anatomy of the Human Spine 
	1.1.1 Curvature of the Spine 
	1.1.2 Vertebrae 
	1.1.3 Cervical Spine 
	1.1.4 Thoracic Spine 
	1.1.5 Lumbar Spine 
	1.1.6 Intervertebral Discs 
	1.1.7 Spinal Cord 
	1.1.8 Bone Physiology and Remodeling 
1.2 Spinal Disorders 
	1.2.1 Degenerative Disc Disease 
	1.2.2 Herniated Disc 
	1.2.3 Spinal Stenosis 
	1.2.4 Spondylosis 
	1.2.5 Spondylolisthesis 
	1.2.6 Rheumatoid Arthritis 
	1.2.7 Paget's Disease 
	1.2.8 Osteoporosis 
	1.2.9 Spinal Fractures 
1.3 Spinal Treatment Options
	1.3.1 Spinal Decompression Technologies 
		1.3.1.1 Corpectomy 
		1.3.1.2 Disectomy 
		1.3.1.3 Foraminotomy/Foraminectomy 
		1.3.1.4 Laminotomy/Laminectomy 
		1.3.1.5 Facetectomy
 
Exhibit 1-1: Prevalence of Lower Back Pain, Selected Countries
Exhibit 1-2: The Human Spine
Exhibit 1-3: Vertebra 
Exhibit 1-4: Intevertebral Disc
Exhibit 1-5: The Spinal Cord 
Exhibit 1-6: Illustrations of Disc Damage and Stenosis 
Exhibit 1-7: Example of Spine Nerve Compression 
Exhibit 1-8: Stages of Spondylolisthesis 
Exhibit 1-9: Osteoporosis 
Exhibit 1-10: Vertebral Compression Fracture 
Exhibit 1-11: Discectomy and Laminectomy Procedure Volumes Forecast, Top 5 EU, U.S., and Japan, 2015-2020 

2. ARTIFICIAL CERVICAL AND LUMBAR DISCS

2.1 Fusion vs. Non-Fusion 
2.2 Total Disc Replacement 
2.3 Artificial Cervical Discs 
	2.3.1 Selected Clinical Evidence Regarding Artificial Cervical Discs 
	2.3.2 Selected Artificial Cervical Discs 
		2.3.2.1 Bryan Cervical Artificial Disc 
		2.3.2.2 Prestige ST Cervical Artificial Disc 
		2.3.2.3 ProDisc-C Disc 
		2.3.2.4 NuVasive PCM Cervical Disc 
		2.3.2.5 Mobi-C Artificial Cervical Disc 
		2.3.2.6 SECURE-C Artificial Cervical Disc 
2.4 Artificial Lumbar Discs 
	2.4.1 Selected Clinical Evidence Regarding Artificial Lumbar Discs 
	2.4.2 Selected Artificial Lumbar Discs 
		2.4.2.1 Charite 
		2.4.2.2 ProDisc-L 
		2.4.2.3 MobiDisc 
		2.4.2.4 M6 
		2.4.2.5 ActivL 
2.5 Market Analysis 
2.6 Competitive Analysis 
	2.6.1 Artificial Cervical Discs 
	2.6.2 Artificial Lumbar Discs 

Exhibit 2-1: Artificial Lumbar Disc Replacement 
Exhibit 2-2: Selected FDA-Approved Cervical Total Disc Replacement Devices 
Exhibit 2-3: Selected FDA-Approved Lumbar Total Disc Replacement Devices 
Exhibit 2-4: Artificial Cervical Discs Market, Selected Countries, 2015-2020 
Exhibit 2-5: Artificial Lumbar Discs Market, Selected Countries, 2015-2020 
Exhibit 2-6: 2015, Artificial Cervical Discs Market, Share by Supplier 
Exhibit 2-7: 2015, Artificial Lumbar Discs Market, Share by Supplier 

3. DYNAMIC STABILIZATION DEVICES
 
3.1 Types of Devices 
3.2 Interspinous Process Decompression Devices 
	3.2.1 DIAM 
	3.2.2 X-Stop 
	3.2.3 Coflex 
	3.2.4 InSpace 
	3.2.5 UniWallis 
3.3 Pedicle Screw-Based Posterior Dynamic Stablization Devices 
	3.3.1 Dynesys 
	3.3.2 Dynamic Stabilization System 
	3.3.3 Transition 
	3.3.4 Isobar 
3.4 Market Forecast
3.5 Competitive Analysis 

Exhibit 3-1: Selected Interspinous Process Spacers
Exhibit 3-2: Selected Pedicle Screw-Based Dynamic Stabilization Systems 
Exhibit 3-3: Dynamic Stabilization Devices Market, Selected Countries, 2015-2020 
Exhibit 3-4: 2015, Dynamic Stabilization Devices Market, Share by Supplier 

4. OTHER MOTION PRESERVATION DEVICES
 
4.1 Facet Replacement Products 
	4.1.1 Market Analysis 
4.2 Annulus Repair 
4.2.1 Market Analysis 
4.3 Disc Nucleus Replacement Technologies 

Exhibit 4-1: Annulus Repair Procedure Volumes Forecast, Selected Countries, 2015-2020 
Exhibit 4-2: Annulus Repair Market Forecast, Selected Countries, 2015-2020 

5. SPINAL FUSION INSTRUMENTATION
 
5.1 Cervical Fusion 
	5.1.1 Anterior Cervical Fusion 
		5.1.1.1 Anterior Cervical Plates 
		5.1.1.2 Anterior Cervical Plates Products 
			5.1.1.2.1 Aesculap/B. Braun Melsungen 
			5.1.1.2.2 Alphatec Spine 
			5.1.1.2.3 DePuy Synthes 
			5.1.1.2.4 Medtronic 
			5.1.1.2.5 Stryker 
			5.1.1.2.6 Zimmer Biomet 
	5.1.2 Posterior Cervical Fusion 
	5.1.3 Cervical Pedicle Screw Systems 
	5.1.4 Interbody Cervical Fusion 
		5.1.4.1 Device Design and Materials 
		5.1.4.2 Selected Clinical Evidence Regarding Cervical Cages 
		5.1.4.3 Selected Cervical Cage Products 
5.2 Thoracic and Lumbar Fusion 
	5.2.1 Thoracic and Lumbar Fusion, by Approach 
	5.2.2 Selected Anterior Lumbar Plating Systems 
	5.2.3 Selected Clinical Evidence Regarding Interbody Fusion (IBF) Cages 
	5.2.4 Selected Lumbar Interbody Fusion Cages 
5.3 Posterior Spinal Fixation Devices 
	5.3.1 Pedicle Screw Systems 
	5.3.2 Selected Clinical Evidence Regarding Pedicle Screw Systems 
	5.3.3 Selected Pedicle Screw Fixation Systems 
5.4 Market Analysis
	5.4.1 Interbody Fusion Devices-Procedures Volumes Forecast and Market Forecast 
	5.4.2 Pedicle Screw Market Forecast 
	5.4.3 Anterior Cervical Plates Market Forecast 
	5.4.4 Spinal Fusion Instrumentation Combined Market Forecast 
5.5 Competitive Analysis 
	5.5.1 Pedicle Screws 
	5.5.2 Interbody Fusion Devices 
	5.5.3 Anterior Column Plating 

Exhibit 5-1: Classification of Anterior Cervical Plates 
Exhibit 5-2: Selected Anterior Cervical Plate Systems 
Exhibit 5-3: Selected Cervical Cage Systems 
Exhibit 5-4: Selected Anterior Lumbar Plating Systems 
Exhibit 5-5: Selected Interbody Fusion Devices 
Exhibit 5-6: Selected Pedicle Screw Fixation Systems 
Exhibit 5-7: Interbody Fusion Procedure Volumes Forecast, by Country, 2015-2020 ('000s) 
Exhibit 5-8: Interbody Fusion Devices Market Forecast, by Country, 2015-2020 ($M) 
Exhibit 5-9: Pedicle Screw Market Forecast, by Country 2015-20 ($M) 
Exhibit 5-10: Anterior Column Plating Market Forecast, by Country 2015-20 ($M) 
Exhibit 5-11: Combined Market Forecast, Spinal Instrumentation, by Country 2015-20 ($M) 
Exhibit 5-12: 2015, Pedicle Screw Market, Share by Supplier 
Exhibit 5-13: 2015, Interbody Fusion Devices Market, Share by Supplier 
Exhibit 5-14: 2015, Anterior Column Plating Systems Market, Share by Supplier 

6. VERTEBRAL COMPRESSION FRACTURE TREATMENT
 
6.1 Vertebroplasty 
	6.1.1 Clinical Evidence Regarding Vertebroplasty 
	6.1.2 Polymethylmethacrylate Alternatives 
	6.1.3 Selected Vertebroplasty Products 
6.2 Kyphoplasty 
6.3 Percutaneous Vertebral Augmentation Systems 
	6.3.1 New or Emerging Percutaneous Vertebral Augmentation Systems
	6.3.2 Selected Percutaneous Vertebral Augmentation Systems 
6.4 Procedure Volumes Forecast-Kyphoplasty and Vertebroplasty 
6.5 Market Forecast
6.6 Competitive Analysis-Vertebroplasty 
6.7 Competitive Analysis-Balloon Kyphoplasty and Percutaneous Vertebral Augmentation Systems 

Exhibit 6-1: Vertebroplasty Indications and Contraindications 
Exhibit 6-2: Selected Vertebroplasty Products 
Exhibit 6-3: Selected Percutaneous Vertebral Augmentation Products 
Exhibit 6-4: Balloon Kyphoplasty and Vertebroplasty Procedure Volumes Forecast, Top 5 EU, U.S. and Japan, 2015-2020 
Exhibit 6-5: Balloon Kyphoplasty/Percutaneous Vertebral Augmentation Systems and Vertebroplasty Market Forecast, Top 5 EU, U.S. and Japan, 2015-2020
Exhibit 6-6: 2015, Vertebroplasty Products Market, Share by Supplier 
Exhibit 6-7: 2015, Balloon Kyphoplasty and Percutaneous Vertebral Augmentation Systems Market, Share by Supplier 

7. EMERGING TECHNOLOGIES
 
7.1 Stem Cell Therapy 
	7.1.1 Selected Products Under Development 
		7.1.1.1 Mesoblast 
		7.1.1.2 NuVasive 
		7.1.1.3 ISTO Technologies 
		7.1.1.4 Orthofix 
7.2 Biologics 
	7.2.1 Selected Products Under Development 
		7.2.1.1 Alphatec Spine 
		7.2.1.2 Stryker 
		7.2.1.3 Zimmer Biomet 
7.3 Tissue Engineering 
	7.3.1 Selected Products Under Development 
		7.3.1.1 DiscGenics 
7.4 Market Analysis for Emerging Technologies 

Exhibit 7-1: Selected Limitations of Alternative Biological Therapies for Spinal Disc Repair 

8. GLOBAL SPINAL IMPLANTS MARKET
 
i. Artificial Cervical and Lumbar Discs 
ii. Dynamic Stabilization Devices 
iii. Annulus Repair Products 
iv. Spinal Fusion Instrumentation 
v. Vertebral Compression Fracture Treatment Products 
vi. Global Spinal Implants Market 

Exhibit 8-1: Global Spinal Implants Market, 2015-2020 
Exhibit 8-2: 2015, Global Spinal Implants Market, Share by Segment 
Exhibit 8-3: 2020, Global Spinal Implants Market, Share by Segment 

APPENDIX A: COMPANY LISTING

APPENDIX B: BIBLIOGRAPHY


COMPANIES COVERED:

  1. Alphatec Spine
  2. Amedica
  3. Atlas Spine
  4. AxioMed Spine
  5. B. Braun Melsungen AG
  6. Benvenue Medical
  7. Biotechni
  8. Carefusion
  9. Crosstrees Medical
  10. DiscGenics
  11. Depuy Synthes/Johnson & Johnson
  12. DFINE
  13. Exactech
  14. Globus Medical
  15. Heraeus Medical
  16. Integra LifeSciences Corp.
  17. Intrinsic Therapeutics
  18. ISTO Technologies
  19. K2M
  20. Life Spine
  21. LDR
  22. Medicrea
  23. Medtronic plc
  24. Mekanika
  25. Mesoblast, Ltd.
  26. NuVasive, Inc.
  27. Ortho Development
  28. Orthofix
  29. Orthopaedic & Spine Development
  30. Osseon, LLC
  31. Paradigm Spine
  32. PINA Medizintechnik Vertriebs AG
  33. Pioneer Surgical
  34. Premia Spine
  35. Signus Medical
  36. Simpirica Spine
  37. Sintea Plustek
  38. Spinal Elements
  39. Spinal Kinetics, Inc.
  40. SpineVision
  41. SpineWave
  42. Stryker
  43. Synimed
  44. Teknimed
  45. Ulrich Medical USA
  46. VertiFlex
  47. Zimmer Biomet
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