During the forecast period covered by this report, the combined U.S. market for osteobiologic and bone growth stimulation products for spine surgery is projected to increase at a compound annual rate of 2.8%, reaching an estimated $2,110.5 million in the year 2016.
This dynamic new report from Medtech Insight includes analyses of the U.S. markets for allograft bone products, electrical osteogenic stimulators, recombinant human bone morphogenetic proteins, and synthetic bone grafts used in spine surgery. Also included in this report are company profiles of the leading competitors in these markets, as well as a clinical overview of the most common spinal diseases/disorders for which spinal fusion is indicated.
EXECUTIVE SUMMARY i. Selected Spinal Disorders a. Degenerative Disc Disease b. Disc Herniation c. Spinal Tumors d. Traumatic Spinal Injuries ii. Allograft Bone Products Used in Spine Surgery a. Market Analysis iii. Synthetic Bone Graft Products Used in Spinal Fusion a. Market Analysis iv. Recombinant Human Bone Morphogenetic Proteins Used in Spinal Fusion a. Market Analysis v. Electrical Osteogenic Stimulators Used in Spinal Fusion a. Market Analysis vi. Combined Market Forecast vii. Methodology Exhibit ES-1: Prevalence of Selected Spinal Disorders, 2011-2016 Exhibit ES-2: Incidence of Selected Spinal Disorders, 2011-2016 Exhibit ES-3: Allograft Bone Products Used in Spine Surgery, Market Forecast, 2011-2016 Exhibit ES-4: Synthetic Bone Graft Substitutes Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2011-2016 Exhibit ES-6: Electrical Osteogenic Stimulators Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit ES-7: Osteobiologic and Bone Growth Stimulation Products for Spine Surgery, Combined Market Forecast, 2011-2016 1. CLINICAL OVERVIEW 1.1 The Human Spine 1.2 Bone Structure and Function 1.2.1 Bone Formation 1.2.2 Cellular Framework 126.96.36.199 Osteoblasts 188.8.131.52 Osteocytes 184.108.40.206 Osteoclasts 1.2.3 The Fracture Healing Process 1.2.4 Factors Affecting Bone Physiology 220.127.116.11 The Effect of Physical Stress on Bone Remodeling 18.104.22.168 Age and Gender 22.214.171.124 Physical Activity 126.96.36.199 Obesity 188.8.131.52 Cigarette Smoking, Alcohol, and Caffeine 184.108.40.206 Nutritional Deficiencies 1.3 Selected Spinal Disorders 1.3.1 Disc Herniation 1.3.2 Degenerative Disc Disease 220.127.116.11 Arthritis 18.104.22.168.1 Osteoarthritis 22.214.171.124.2 Rheumatoid Arthritis 126.96.36.199.3 Ankylosing Spondylitis 188.8.131.52 Osteoporosis 184.108.40.206 Spondylosis 1.3.3 Abnormal Curvature of the Spine 220.127.116.11 Scoliosis 18.104.22.168 Kyphosis and Lordosis 1.3.4 Spondylolisthesis 1.3.5 Stenosis 1.3.6 Spinal Tumors 1.3.7 Traumatic Spinal Injuries 1.3.8 Vertebral Fractures 1.4 Spine Treatment Options 1.4.1 Spinal Decompression 22.214.171.124 Corpectomy 126.96.36.199 Discectomy 188.8.131.52 Facetectomy 184.108.40.206 Foraminotomy/Foraminectomy 220.127.116.11 Laminotomy/Laminectomy 1.4.2 Spinal Fusion 18.104.22.168 Instrumented versus Noninstrumented Spinal Fusion 22.214.171.124.1 Instrumented Spinal Fusion 126.96.36.199.2 Noninstrumented Spinal Fusion 188.8.131.52 Types of Fusion 184.108.40.206.1 Cervical Fusion 220.127.116.11.2 Anterior Cervical Fusion 18.104.22.168.3 Posterior Cervical Fusion 22.214.171.124.4 Interbody Fusion 126.96.36.199.5 Lumbar Fusion 188.8.131.52.5.1 Anterior Lumbar Interbody Fusion 184.108.40.206.5.2 Posterior Lumbar Interbody Fusion 220.127.116.11.5.3 Transforaminal Lumbar Interbody Fusion 18.104.22.168.6 Posterolateral Fusion 22.214.171.124.7 360-Degree Fusion 126.96.36.199.8 Thoracic and Thoracolumbar Fusion 188.8.131.52.9 Percutaneous or Minimally Invasive Fusion 1.4.3 Posterior Dynamic Stabilization 1.5 Market Dynamics 1.5.1 Demographics 1.5.2 Reimbursement 1.5.3 Patient Protection and Affordable Care Act 1.5.4 Federal Oversight of Physician/Corporate Relationships 1.5.5 Procedure Volumes Forecast Exhibit 1-1: The Human Spine Exhibit 1-2: The Structure of Collagen Exhibit 1-3: The Structure of Hydroxyapatite Exhibit 1-4: The Structure of Bone Exhibit 1-5: Bone Density Averages in the General Population Exhibit 1-6: Bone Density Averages in Olympic Athletes in Comparison with the General Population Exhibit 1-7: Number of Overweight and Obese People, 2011 and 2016 Exhibit 1-8: A Herniated Disc Exhibit 1-9: Bone Density in Normal and Osteoporotic Bone Tissue Exhibit 1-10: Prevalence of Selected Spinal Disorders, 2011-2016 Exhibit 1-11: Incidence of Selected Spinal Disorders, 2011-2016 Exhibit 1-12: The Anatomy of a Spinal Segment Exhibit 1-13: Noninstrumented Spinal Fusion Exhibit 1-14: United States Population Growth Trends Exhibit 1-15: Spinal Fusion Diagnosis-Related Groups and Associated Medicare Reimbursement Exhibit 1-16: Spinal Fusion, Procedure Volumes Forecast, 2010-2016 2. ALLOGRAFT BONE PRODUCTS USED IN SPINE SURGERY 2.1 Regulations Governing Allograft Providers 2.2 Processing Allograft Bone 2.2.1 Tissue Recovery 2.2.2 Tissue Processing 2.3 Allograft Forms 2.3.1 Support Structures 2.3.2 Osteoconductive Fillers 2.3.3 Osteoinductive Materials 2.4 Allograft Tissue Providers 2.5 Market Analysis 2.5.1 Allograft Structural Elements 2.5.2 Allograft Fillers 2.5.3 Demineralized Bone Matrix 2.6 Competitive Analysis Exhibit 2-1: 2012, Selected Allograft Bone Products Used in Spine Surgery Exhibit 2-2: 2012, Selected Demineralized Bone Matrix Products Exhibit 2-3: 2011, Comparison of Allograft Sales, by Distribution Channel Exhibit 2-4: Allograft Bone Products Used in Spine Surgery, Market Forecast, 2011-2016 Exhibit 2-5: Allograft Bone Products Used in Spine Surgery, Market Segment Shares, 2011 and 2016 Exhibit 2-6: 2011, Market for Allograft Bone Products Used in Spine Surgery, Share by Supplier 3. SYNTHETIC BONE GRAFT PRODUCTS USED IN SPINAL FUSION 3.1 Products 3.2 Emerging Products 3.3 Market Analysis 3.4 Competitive Analysis Exhibit 3-1: 2012, Selected Synthetic Bone Graft Products Used in Spinal Fusion Exhibit 3-2: Synthetic Bone Graft Substitutes Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit 3-3: 2011, Market for Synthetic Bone Graft Substitutes Used in Spinal Fusion, Share by Supplier 4. RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEINS USED IN SPINAL FUSION 4.1 Products 4.1.1 Infuse Bone Graft 4.1.2 Osteogenic Protein-1 4.2 Emerging Products 4.3 Market Analysis Exhibit 4-1: Selected Bone Morphogenetic Proteins Exhibit 4-2: 2012, Selected Recombinant Human Bone Morphogenetic Protein Products Exhibit 4-3: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2011-2016 5. ELECTRICAL OSTEOGENIC STIMULATORS USED IN SPINAL FUSION 5.1 Direct Current Electrical Osteogenic Stimulation 5.2 Capacitive Coupling Electrical Osteogenic Stimulation 5.3 Combined Magnetic Field Osteogenic Stimulation 5.4 Pulsed Electromagnetic Field Osteogenic Stimulation 5.5 Reimbursement 5.6 Products 5.7 Market Analysis 5.8 Competitive Analysis Exhibit 5-1: Direct Current Osteogenic Stimulators Exhibit 5-2: Capacitive Coupling Osteogenic Stimulator Exhibit 5-3: Combined Magnetic Field Osteogenic Stimulator Exhibit 5-4: External Pulsed Electromagnetic Field Osteogenic Stimulators Exhibit 5-5: Selected Indications for Electrical Osteogenic Stimulation Used in Spinal Fusion Exhibit 5-6: 2012, Electrical Osteogenic Stimulator Products Used in Spinal Fusion Exhibit 5-7: Electrical Osteogenic Stimulators Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit 5-8: 2011, Market for Electrical Osteogenic Stimulators Used in Spinal Fusion, Share by Supplier 6. COMPANY PROFILES 6.1 AlloSource, Inc. 6.2 Biomet, Inc. 6.3 Integra LifeSciences Corporation 6.4 LifeNet Health, Inc. 6.5 Medtronic, Inc. 6.6 Musculoskeletal Transplant Foundation 6.7 Orthofix International NV 6.8 Stryker Corporation APPENDIX: COMPANY LISTING