U.S. MARKETS FOR OSTEOBIOLOGIC AND BONE GROWTH STIMULATION PRODUCTS FOR SPINE SURGERY

160 Pages | 43 Exhibits | 2012 Analysis | Forecasts Through 2016 Product Family: Market Reports




OVERVIEW:
According to the United States (U.S.) Department of Health & Human Services, back pain accounts for approximately 13.4 million physician office visits and 3.7 million emergency room visits annually. Degeneration of an intervertebral disc that results in functionally limiting low back pain is a common condition that prompts patients to seek treatment. To eliminate or reduce pain and restore quality of life, patients with acute, debilitating pain may require spinal fusion.

During the forecast period covered by this report, the combined U.S. market for osteobiologic and bone growth stimulation products for spine surgery is projected to increase at a compound annual rate of 2.8%, reaching an estimated $2,110.5 million in the year 2016.

This dynamic new report from Medtech Insight includes analyses of the U.S. markets for allograft bone products, electrical osteogenic stimulators, recombinant human bone morphogenetic proteins, and synthetic bone grafts used in spine surgery. Also included in this report are company profiles of the leading competitors in these markets, as well as a clinical overview of the most common spinal diseases/disorders for which spinal fusion is indicated.

TABLE OF CONTENTS:
EXECUTIVE SUMMARY

i. Selected Spinal Disorders 
	a. Degenerative Disc Disease 
	b. Disc Herniation 
	c. Spinal Tumors 
	d. Traumatic Spinal Injuries 
ii. Allograft Bone Products Used in Spine Surgery 
	a. Market Analysis 
iii. Synthetic Bone Graft Products Used in Spinal Fusion 
	a. Market Analysis 
iv. Recombinant Human Bone Morphogenetic Proteins Used in Spinal Fusion 
	a. Market Analysis 
v. Electrical Osteogenic Stimulators Used in Spinal Fusion 
	a. Market Analysis 
vi. Combined Market Forecast 
vii. Methodology 

Exhibit ES-1: Prevalence of Selected Spinal Disorders, 2011-2016 
Exhibit ES-2: Incidence of Selected Spinal Disorders, 2011-2016 
Exhibit ES-3: Allograft Bone Products Used in Spine Surgery, Market Forecast, 2011-2016 
Exhibit ES-4: Synthetic Bone Graft Substitutes Used in Spinal Fusion, Market Forecast, 2011-2016 
Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2011-2016 
Exhibit ES-6: Electrical Osteogenic Stimulators Used in Spinal Fusion, Market Forecast, 2011-2016 
Exhibit ES-7: Osteobiologic and Bone Growth Stimulation Products for Spine Surgery, Combined Market Forecast, 2011-2016 

1. CLINICAL OVERVIEW

1.1 The Human Spine 
1.2 Bone Structure and Function 
	1.2.1 Bone Formation 
	1.2.2 Cellular Framework 
		1.2.2.1 Osteoblasts 
		1.2.2.2 Osteocytes 
		1.2.2.3 Osteoclasts 
	1.2.3 The Fracture Healing Process 
	1.2.4 Factors Affecting Bone Physiology 
		1.2.4.1 The Effect of Physical Stress on Bone Remodeling 
		1.2.4.2 Age and Gender 
		1.2.4.3 Physical Activity 
		1.2.4.4 Obesity 
		1.2.4.5 Cigarette Smoking, Alcohol, and Caffeine 
		1.2.4.6 Nutritional Deficiencies 
1.3 Selected Spinal Disorders 
	1.3.1 Disc Herniation 
	1.3.2 Degenerative Disc Disease 
		1.3.2.1 Arthritis 
			1.3.2.1.1 Osteoarthritis 
			1.3.2.1.2 Rheumatoid Arthritis 
			1.3.2.1.3 Ankylosing Spondylitis 
		1.3.2.2 Osteoporosis 
		1.3.2.3 Spondylosis 
	1.3.3 Abnormal Curvature of the Spine 
		1.3.3.1 Scoliosis 
		1.3.3.2 Kyphosis and Lordosis 
	1.3.4 Spondylolisthesis 
	1.3.5 Stenosis 
	1.3.6 Spinal Tumors 
	1.3.7 Traumatic Spinal Injuries 
	1.3.8 Vertebral Fractures 
1.4 Spine Treatment Options 
	1.4.1 Spinal Decompression 
		1.4.1.1 Corpectomy 
		1.4.1.2 Discectomy 
		1.4.1.3 Facetectomy 
		1.4.1.4 Foraminotomy/Foraminectomy 
		1.4.1.5 Laminotomy/Laminectomy 
	1.4.2 Spinal Fusion 
		1.4.2.1 Instrumented versus Noninstrumented Spinal Fusion 
			1.4.2.1.1 Instrumented Spinal Fusion 
			1.4.2.1.2 Noninstrumented Spinal Fusion 
		1.4.2.2 Types of Fusion 
			1.4.2.2.1 Cervical Fusion 
			1.4.2.2.2 Anterior Cervical Fusion 
			1.4.2.2.3 Posterior Cervical Fusion 
			1.4.2.2.4 Interbody Fusion 
			1.4.2.2.5 Lumbar Fusion 
				1.4.2.2.5.1 Anterior Lumbar Interbody Fusion
				1.4.2.2.5.2 Posterior Lumbar Interbody Fusion 
				1.4.2.2.5.3 Transforaminal Lumbar Interbody Fusion 
			1.4.2.2.6 Posterolateral Fusion 
			1.4.2.2.7 360-Degree Fusion
			1.4.2.2.8 Thoracic and Thoracolumbar Fusion 
			1.4.2.2.9 Percutaneous or Minimally Invasive Fusion 
	1.4.3 Posterior Dynamic Stabilization 
1.5 Market Dynamics 
	1.5.1 Demographics 
	1.5.2 Reimbursement 
	1.5.3 Patient Protection and Affordable Care Act 
	1.5.4 Federal Oversight of Physician/Corporate Relationships 
	1.5.5 Procedure Volumes Forecast 

Exhibit 1-1: The Human Spine 
Exhibit 1-2: The Structure of Collagen 
Exhibit 1-3: The Structure of Hydroxyapatite 
Exhibit 1-4: The Structure of Bone 
Exhibit 1-5: Bone Density Averages in the General Population 
Exhibit 1-6: Bone Density Averages in Olympic Athletes in Comparison  with the General Population 
Exhibit 1-7: Number of Overweight and Obese People, 2011 and 2016 
Exhibit 1-8: A Herniated Disc 
Exhibit 1-9: Bone Density in Normal and Osteoporotic Bone Tissue 
Exhibit 1-10: Prevalence of Selected Spinal Disorders, 2011-2016 
Exhibit 1-11: Incidence of Selected Spinal Disorders, 2011-2016 
Exhibit 1-12: The Anatomy of a Spinal Segment 
Exhibit 1-13: Noninstrumented Spinal Fusion 
Exhibit 1-14: United States Population Growth Trends 
Exhibit 1-15: Spinal Fusion Diagnosis-Related Groups and Associated Medicare Reimbursement 
Exhibit 1-16: Spinal Fusion, Procedure Volumes Forecast, 2010-2016 

2. ALLOGRAFT BONE PRODUCTS USED IN SPINE SURGERY

2.1 Regulations Governing Allograft Providers 
2.2 Processing Allograft Bone 
	2.2.1 Tissue Recovery 
	2.2.2 Tissue Processing 
2.3 Allograft Forms 
	2.3.1 Support Structures 
	2.3.2 Osteoconductive Fillers 
	2.3.3 Osteoinductive Materials 
2.4 Allograft Tissue Providers 
2.5 Market Analysis 
	2.5.1 Allograft Structural Elements 
	2.5.2 Allograft Fillers 
	2.5.3 Demineralized Bone Matrix 
2.6 Competitive Analysis 

Exhibit 2-1: 2012, Selected Allograft Bone Products Used in Spine Surgery 
Exhibit 2-2: 2012, Selected Demineralized Bone Matrix Products 
Exhibit 2-3: 2011, Comparison of Allograft Sales, by Distribution Channel 
Exhibit 2-4: Allograft Bone Products Used in Spine Surgery, Market Forecast, 2011-2016 
Exhibit 2-5: Allograft Bone Products Used in Spine Surgery, Market Segment Shares, 2011 and 2016 
Exhibit 2-6: 2011, Market for Allograft Bone Products Used in Spine Surgery, Share by Supplier 

3. SYNTHETIC BONE GRAFT PRODUCTS USED IN SPINAL FUSION

3.1 Products 
3.2 Emerging Products 
3.3 Market Analysis 
3.4 Competitive Analysis 

Exhibit 3-1: 2012, Selected Synthetic Bone Graft Products Used in Spinal Fusion 
Exhibit 3-2: Synthetic Bone Graft Substitutes Used in Spinal Fusion, Market Forecast, 2011-2016 
Exhibit 3-3: 2011, Market for Synthetic Bone Graft Substitutes Used in Spinal Fusion, Share by Supplier 

4. RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEINS USED IN SPINAL FUSION

4.1 Products 
	4.1.1 Infuse Bone Graft 
	4.1.2 Osteogenic Protein-1 
4.2 Emerging Products 
4.3 Market Analysis 

Exhibit 4-1: Selected Bone Morphogenetic Proteins 
Exhibit 4-2: 2012, Selected Recombinant Human Bone Morphogenetic Protein Products 
Exhibit 4-3: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2011-2016 

5. ELECTRICAL OSTEOGENIC STIMULATORS USED IN SPINAL FUSION

5.1 Direct Current Electrical Osteogenic Stimulation 
5.2 Capacitive Coupling Electrical Osteogenic Stimulation 
5.3 Combined Magnetic Field Osteogenic Stimulation 
5.4 Pulsed Electromagnetic Field Osteogenic Stimulation 
5.5 Reimbursement 
5.6 Products 
5.7 Market Analysis 
5.8 Competitive Analysis 

Exhibit 5-1: Direct Current Osteogenic Stimulators 
Exhibit 5-2: Capacitive Coupling Osteogenic Stimulator 
Exhibit 5-3: Combined Magnetic Field Osteogenic Stimulator 
Exhibit 5-4: External Pulsed Electromagnetic Field Osteogenic Stimulators 
Exhibit 5-5: Selected Indications for Electrical Osteogenic Stimulation Used in Spinal Fusion 
Exhibit 5-6: 2012, Electrical Osteogenic Stimulator Products Used in Spinal Fusion 
Exhibit 5-7: Electrical Osteogenic Stimulators Used in Spinal Fusion, Market Forecast, 2011-2016 
Exhibit 5-8: 2011, Market for Electrical Osteogenic Stimulators Used in Spinal Fusion, Share by Supplier 

6. COMPANY PROFILES

6.1 AlloSource, Inc. 
6.2 Biomet, Inc. 
6.3 Integra LifeSciences Corporation 
6.4 LifeNet Health, Inc. 
6.5 Medtronic, Inc. 
6.6 Musculoskeletal Transplant Foundation 
6.7 Orthofix International NV 
6.8 Stryker Corporation 

APPENDIX:  COMPANY LISTING 


COMPANIES COVERED:

  1. Aesculap, Inc./ B. Braun Melsungen AG
  2. AlloSource, Inc.
  3. Alphatec Spine, Inc.
  4. Astellas Pharma, Inc.
  5. Baxter International, Inc.
  6. Biocomposites LTD
  7. Biomet, Inc.
  8. BoneSupport AB
  9. Cerapedics, Inc.
  10. DePuy Synthes/Johnson & Johnson
  11. DJO Global LLC
  12. Exactech, Inc.
  13. Globus Medical, Inc.
  14. Hans Biomed Corporation
  15. Integra LifeSciences Corporation
  16. International Biologics LLC
  17. ISTO Technologies, Inc.
  18. Lanx, Inc.
  19. LifeLink Tissue Bank/ LifeLink Foundation
  20. LifeNet Health, Inc.
  21. Medtronic, Inc.
  22. Musculoskeletal Transplant Foundation
  23. NovaBone Products LLC
  24. NuTech Spine, Inc.
  25. NuVasive, Inc
  26. Olympus Biotech Corporation/ Olympus Corporation
  27. Orthofix International NV
  28. Osprey Biomedical Corporation
  29. Osteotech, Inc./Medtronic, Inc.
  30. Performance Grafts LLC
  31. Pfizer, Inc.
  32. Pioneer Surgical Technology, Inc.
  33. Royal DSM NA
  34. RTI Biologics, Inc.
  35. Smith & Nephew, Inc.
  36. Spinal Elements, Inc.
  37. Spineology, Inc.
  38. Stability Biologics LLC
  39. Stryker Corporation
  40. Surgical Tissue Network, Inc.
  41. Tissue Banks International
  42. Wright Medical Technology, Inc./ Wright Medical Group
  43. Zimmer Spine/Zimmer, Inc.
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