This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for biomaterial products for bone healing/regeneration and spinal fusion indications. This market, as covered by the scope of this report, includes bioresorbable fixation devices (pins, screws, tacks, suture anchors, and meniscal repair devices); allografts and bone replacement materials (base tissue, demineralized bone matrix, machined bone allografts, and synthetic bone grafts), and osteobiologics (autologous therapy/platelet concentrate systems, gene therapy, platelet-derived growth factors, recombinant human bone morphogenetic proteins, small molecule therapies, and stem cells). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for bone repair and regeneration is projected to reach an estimated value of $3.5 billion in the year 2017.
This is the first of two reports covering the U.S. market for orthopedic biomaterials. Report #A322, "U.S. Markets for Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration" has also published.
EXECUTIVE SUMMARY i. Bioresorbable Fixation Devices ii. Bone Allograft and Synthetic Bone Graft Products iii. Osteobiologics iv. Combined Market Forecast v. Methodology Exhibit ES-1: Types of Bioresorbable Fixation Devices Exhibit ES-2: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit ES-3: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit ES-4: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit ES-6: Osteobiologics, Market Forecast, 2012-2017 Exhibit ES-7: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit ES-8: Orthopedic Biomaterials for Bone Repair and Regeneration, Combined Market Forecast, 2012-2017 1. MUSCULOSKELETAL SYSTEM OVERVIEW 1.1 Bone Structure and Function 1.1.1 Cellular Framework 18.104.22.168 Osteoblasts 22.214.171.124 Osteocytes 126.96.36.199 Osteoclasts 188.8.131.52 Osteogenesis 1.1.2 Bone Tissue 184.108.40.206 Cancellous and Cortical Bone Tissue 220.127.116.11 Bone Marrow 1.1.3 Bone Anatomy 18.104.22.168 Diaphysis and Epiphysis 22.214.171.124 Endosteum 126.96.36.199 Periosteum 1.1.4 Joint Components 188.8.131.52 Cartilage 184.108.40.206.1 Elastic Cartilage 220.127.116.11.2 Fibrocartilage 18.104.22.168.3 Hyaline Cartilage 22.214.171.124 Bursae 126.96.36.199 Joint Cavity 188.8.131.52 Menisci 184.108.40.206 Synovial Membrane and Fluid 220.127.116.11 Ligaments and Tendons 18.104.22.168 Muscles 1.1.5 Joint Structures 22.214.171.124 Ankle 126.96.36.199 Digits 188.8.131.52 Elbow 184.108.40.206 Hip 220.127.116.11 Knee 18.104.22.168 Shoulder 22.214.171.124 Wrist 1.1.6 Bone Formation and Remodeling 126.96.36.199 In the Fetus 188.8.131.52 In Childhood 184.108.40.206 In Adulthood 220.127.116.11 In Old Age 18.104.22.168 Mechanical Stress and Wolff's Law 1.1.7 Factors Affecting Bone Physiology 22.214.171.124 Age 126.96.36.199 Gender 188.8.131.52 Genetic Disposition 184.108.40.206 Hormonal Activity 220.127.116.11 Physical Activity 18.104.22.168 Cigarette Smoking 22.214.171.124 Alcohol and Caffeine Intake 126.96.36.199 Nutritional Deficiencies 1.2 Joint Structure and Function 1.2.1 Types of Joints 188.8.131.52 Synarthroses 184.108.40.206 Amphiarthroses 220.127.116.11 Diarthroses 18.104.22.168.1 Ball-and-Socket 22.214.171.124.2 Condyloid 126.96.36.199.3 Hinge 188.8.131.52.4 Gliding 184.108.40.206.5 Pivot 1.2.2 Arthritis 220.127.116.11 Osteoarthritis 18.104.22.168 Rheumatoid Arthritis 1.3 Management of Joint Disorders 1.3.1 Joint Replacement 22.214.171.124 Dislocation 126.96.36.199 Ligament and Tendon Injuries 188.8.131.52 Meniscal Injuries Exhibit 1-1: Illustration of Bone Tissue Exhibit 1-2: Types of Cartilage Exhibit 1-3: Stages of Bone Remodeling 2. BIORESORBABLE FIXATION DEVICES 2.1 Materials 2.2 Products 2.2.1 Bioresorbable Pins 2.2.2 Bioresorbable Screws, Nails, and Tacks 2.2.3 Bioresorbable Interference Screws 2.2.4 Bioresorbable Suture Anchors 2.2.5 Bioresorbable Meniscal Repair Devices 2.3 Market Analysis 2.3.1 Potential Market for Bioresorbable Fixation Devices 184.108.40.206 Meniscal Repair 220.127.116.11 Cruciate Ligament Fixation 18.104.22.168 Shoulder Reconstruction 22.214.171.124 Small Joint/Bone Fragment Fixation 2.4 Competitive Analysis Exhibit 2-1: Advantages of Bioresorbable Fixation Devices Exhibit 2-2: Factors Affecting the Properties of Bioresorbable Polymers Exhibit 2-3: Types of Bioresorbable Fixation Devices Exhibit 2-4: 2013, Selected Bioresorbable Pins Exhibit 2-5: 2013, Selected Bioresorbable Nails, Screws, and Tacks Exhibit 2-6: 2013, Selected Bioresorbable Interference Screws Exhibit 2-7: 2013, Selected Bioresorbable Suture Anchors Exhibit 2-8: 2013, Selected Bioresorbable Meniscal Repair Devices Exhibit 2-9: 2012, Bioresorbable Fixation Devices Market, By Procedure Type Exhibit 2-10: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit 2-11: 2012, Bioresorbable Fixation Devices Market, Share by Supplier 3. BONE ALLOGRAFT AND SYNTHETIC BONE GRAFT PRODUCTS 3.1 Bone Graft Materials 3.1.1 Autograft 3.1.2 Allograft 126.96.36.199 Regulations Governing Allograft Providers 188.8.131.52.1 National Organ Transplant Act 184.108.40.206.2 United States Food and Drug Administration Requirements 220.127.116.11 Donor Screening 18.104.22.168 Recovering Tissue 22.214.171.124 Processing Tissue 126.96.36.199 Tissue Banking Industry 188.8.131.52 Base Tissue 184.108.40.206 Demineralized Bone Matrix Products 220.127.116.11 Machined Bone 3.2 Synthetic Bone Grafts 3.2.1 Products 3.3 Bone Graft Applications 3.3.1 Fracture Repair 3.3.2 Revision Total Joint Surgery 3.3.3 Tumors 3.3.4 Spine 3.4 Market Analysis 3.5 Competitive Analysis 3.5.1 Demineralized Bone Matrix 3.5.2 Machined Bone Allografts 3.5.3 Synthetic Bone Graft Substitutes Exhibit 3-1: Selected Categories of Bone Grafts Exhibit 3-2: Base Tissue Bone Allograft Applications in Orthopedic Surgery Exhibit 3-3: Base Tissue Bone Allograft Applications in Spine Surgery Exhibit 3-4: 2013, Description and Representative Pricing of Base Allografts Used in Spine Surgery Exhibit 3-5: 2013, Selected Demineralized Bone Matrix Products Exhibit 3-6: 2013, Selected Machined Bone Allografts Exhibit 3-7: Materials Used in Bone Graft Substitutes Exhibit 3-8: 2013, Selected Synthetic Bone Grafts Exhibit 3-9: Applications for Bone Grafts Exhibit 3-10: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit 3-11: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit 3-12: 2012, Demineralized Bone Matrix Products Market, Share by Supplier Exhibit 3-13: 2012, Machined Bone Allografts Market, Share by Supplier Exhibit 3-14: 2012, Synthetic Bone Grafts Market, Share by Supplier 4. OSTEOBIOLOGICS 4.1 Bone Growth Factors 4.1.1 Bone Morphogenetic Proteins 18.104.22.168 Products 22.214.171.124.1 Infuse Bone Graft 126.96.36.199.2 Osteogenic Protein-1 188.8.131.52 Emerging Products 184.108.40.206 Clinical Trials 4.1.2 Fibroblast Growth Factors 4.1.3 Recombinant Platelet-Derived Growth Factor 220.127.116.11 Products 4.1.4 Autologous (Blood-Derived) Growth Factors 18.104.22.168 Products 4.2 Small Molecules 4.3 Stem Cell Therapy 4.3.1 Products 4.3.2 Emerging Products 4.4 Gene Therapy 4.4.1 Gene Therapy versus Growth Factors 4.4.2 Systemic Gene Therapy 4.4.3 Regional Gene Therapy 4.5 Other Osteobiologics 4.6 Market Analysis 4.6.1 Bone Morphogenetic Proteins 4.6.2 Other Osteobiologics 4.7 Competitive Analysis Exhibit 4-1: Selected Bone Morphogenetic Proteins Exhibit 4-2: Selected Recombinant Human Bone Morphogenetic Protein Products Exhibit 4-3: Selected Recombinant Human Bone Morphogenetic Proteins Under Development Exhibit 4-4: 2013, Selected Autologous Therapy/Platelet Concentrate Systems Exhibit 4-5: 2013, Selected Growth Factor and Small Molecule Therapies Under Development for Bone Healing and Spinal Fusion Applications Exhibit 4-6: 2013, Selected Stem Cell Products for Bone Healing and Enhancement of Spinal Fusion Exhibit 4-7: 2013, Selected Stem Cell Products Under Development for Orthopedic and Spinal Fusion Applications Exhibit 4-8: Comparison of Growth Factors with Gene Therapyfor Bone Repair Exhibit 4-9: Gene Therapy Delivery Methods for Bone Repair Exhibit 4-10: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit 4-11: Stem Cells and Other Osteobiologic Agents for Bone Healing and Enhancement of Spinal Fusion, Market Forecast, 2012-2017 Exhibit 4-12: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit 4-13: 2012, Stem Cell Products Market for Bone Healing and Spinal Fusion, Share by Supplier 5. COMPANY PROFILES 5.1 Arthrex, Inc. 5.2 Baxter International, Inc. 5.3 DiFusion Technologies 5.4 Johnson & Johnson 5.5 LifeNet Health, Inc. 5.6 Medtronic, Inc. 5.7 Musculoskeletal Transplant Foundation, Inc. 5.8 NuVasive, Inc. 5.9 Orthofix International NV 5.10 RTI Biologics, Inc. 5.11 Smith & Nephew PLC 5.12 Stryker Corporation APPENDIX: COMPANY LISTING