This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for biomaterial products for bone healing/regeneration and spinal fusion indications. This market, as covered by the scope of this report, includes bioresorbable fixation devices (pins, screws, tacks, suture anchors, and meniscal repair devices); allografts and bone replacement materials (base tissue, demineralized bone matrix, machined bone allografts, and synthetic bone grafts), and osteobiologics (autologous therapy/platelet concentrate systems, gene therapy, platelet-derived growth factors, recombinant human bone morphogenetic proteins, small molecule therapies, and stem cells). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for bone repair and regeneration is projected to reach an estimated value of $3.5 billion in the year 2017.
This is the first of two reports covering the U.S. market for orthopedic biomaterials. Report #A322, "U.S. Markets for Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration" has also published.
EXECUTIVE SUMMARY i. Bioresorbable Fixation Devices ii. Bone Allograft and Synthetic Bone Graft Products iii. Osteobiologics iv. Combined Market Forecast v. Methodology Exhibit ES-1: Types of Bioresorbable Fixation Devices Exhibit ES-2: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit ES-3: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit ES-4: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit ES-6: Osteobiologics, Market Forecast, 2012-2017 Exhibit ES-7: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit ES-8: Orthopedic Biomaterials for Bone Repair and Regeneration, Combined Market Forecast, 2012-2017 1. MUSCULOSKELETAL SYSTEM OVERVIEW 1.1 Bone Structure and Function 1.1.1 Cellular Framework 220.127.116.11 Osteoblasts 18.104.22.168 Osteocytes 22.214.171.124 Osteoclasts 126.96.36.199 Osteogenesis 1.1.2 Bone Tissue 188.8.131.52 Cancellous and Cortical Bone Tissue 184.108.40.206 Bone Marrow 1.1.3 Bone Anatomy 220.127.116.11 Diaphysis and Epiphysis 18.104.22.168 Endosteum 22.214.171.124 Periosteum 1.1.4 Joint Components 126.96.36.199 Cartilage 188.8.131.52.1 Elastic Cartilage 184.108.40.206.2 Fibrocartilage 220.127.116.11.3 Hyaline Cartilage 18.104.22.168 Bursae 22.214.171.124 Joint Cavity 126.96.36.199 Menisci 188.8.131.52 Synovial Membrane and Fluid 184.108.40.206 Ligaments and Tendons 220.127.116.11 Muscles 1.1.5 Joint Structures 18.104.22.168 Ankle 22.214.171.124 Digits 126.96.36.199 Elbow 188.8.131.52 Hip 184.108.40.206 Knee 220.127.116.11 Shoulder 18.104.22.168 Wrist 1.1.6 Bone Formation and Remodeling 22.214.171.124 In the Fetus 126.96.36.199 In Childhood 188.8.131.52 In Adulthood 184.108.40.206 In Old Age 220.127.116.11 Mechanical Stress and Wolff's Law 1.1.7 Factors Affecting Bone Physiology 18.104.22.168 Age 22.214.171.124 Gender 126.96.36.199 Genetic Disposition 188.8.131.52 Hormonal Activity 184.108.40.206 Physical Activity 220.127.116.11 Cigarette Smoking 18.104.22.168 Alcohol and Caffeine Intake 22.214.171.124 Nutritional Deficiencies 1.2 Joint Structure and Function 1.2.1 Types of Joints 126.96.36.199 Synarthroses 188.8.131.52 Amphiarthroses 184.108.40.206 Diarthroses 220.127.116.11.1 Ball-and-Socket 18.104.22.168.2 Condyloid 22.214.171.124.3 Hinge 126.96.36.199.4 Gliding 188.8.131.52.5 Pivot 1.2.2 Arthritis 184.108.40.206 Osteoarthritis 220.127.116.11 Rheumatoid Arthritis 1.3 Management of Joint Disorders 1.3.1 Joint Replacement 18.104.22.168 Dislocation 22.214.171.124 Ligament and Tendon Injuries 126.96.36.199 Meniscal Injuries Exhibit 1-1: Illustration of Bone Tissue Exhibit 1-2: Types of Cartilage Exhibit 1-3: Stages of Bone Remodeling 2. BIORESORBABLE FIXATION DEVICES 2.1 Materials 2.2 Products 2.2.1 Bioresorbable Pins 2.2.2 Bioresorbable Screws, Nails, and Tacks 2.2.3 Bioresorbable Interference Screws 2.2.4 Bioresorbable Suture Anchors 2.2.5 Bioresorbable Meniscal Repair Devices 2.3 Market Analysis 2.3.1 Potential Market for Bioresorbable Fixation Devices 188.8.131.52 Meniscal Repair 184.108.40.206 Cruciate Ligament Fixation 220.127.116.11 Shoulder Reconstruction 18.104.22.168 Small Joint/Bone Fragment Fixation 2.4 Competitive Analysis Exhibit 2-1: Advantages of Bioresorbable Fixation Devices Exhibit 2-2: Factors Affecting the Properties of Bioresorbable Polymers Exhibit 2-3: Types of Bioresorbable Fixation Devices Exhibit 2-4: 2013, Selected Bioresorbable Pins Exhibit 2-5: 2013, Selected Bioresorbable Nails, Screws, and Tacks Exhibit 2-6: 2013, Selected Bioresorbable Interference Screws Exhibit 2-7: 2013, Selected Bioresorbable Suture Anchors Exhibit 2-8: 2013, Selected Bioresorbable Meniscal Repair Devices Exhibit 2-9: 2012, Bioresorbable Fixation Devices Market, By Procedure Type Exhibit 2-10: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit 2-11: 2012, Bioresorbable Fixation Devices Market, Share by Supplier 3. BONE ALLOGRAFT AND SYNTHETIC BONE GRAFT PRODUCTS 3.1 Bone Graft Materials 3.1.1 Autograft 3.1.2 Allograft 22.214.171.124 Regulations Governing Allograft Providers 126.96.36.199.1 National Organ Transplant Act 188.8.131.52.2 United States Food and Drug Administration Requirements 184.108.40.206 Donor Screening 220.127.116.11 Recovering Tissue 18.104.22.168 Processing Tissue 22.214.171.124 Tissue Banking Industry 126.96.36.199 Base Tissue 188.8.131.52 Demineralized Bone Matrix Products 184.108.40.206 Machined Bone 3.2 Synthetic Bone Grafts 3.2.1 Products 3.3 Bone Graft Applications 3.3.1 Fracture Repair 3.3.2 Revision Total Joint Surgery 3.3.3 Tumors 3.3.4 Spine 3.4 Market Analysis 3.5 Competitive Analysis 3.5.1 Demineralized Bone Matrix 3.5.2 Machined Bone Allografts 3.5.3 Synthetic Bone Graft Substitutes Exhibit 3-1: Selected Categories of Bone Grafts Exhibit 3-2: Base Tissue Bone Allograft Applications in Orthopedic Surgery Exhibit 3-3: Base Tissue Bone Allograft Applications in Spine Surgery Exhibit 3-4: 2013, Description and Representative Pricing of Base Allografts Used in Spine Surgery Exhibit 3-5: 2013, Selected Demineralized Bone Matrix Products Exhibit 3-6: 2013, Selected Machined Bone Allografts Exhibit 3-7: Materials Used in Bone Graft Substitutes Exhibit 3-8: 2013, Selected Synthetic Bone Grafts Exhibit 3-9: Applications for Bone Grafts Exhibit 3-10: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit 3-11: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit 3-12: 2012, Demineralized Bone Matrix Products Market, Share by Supplier Exhibit 3-13: 2012, Machined Bone Allografts Market, Share by Supplier Exhibit 3-14: 2012, Synthetic Bone Grafts Market, Share by Supplier 4. OSTEOBIOLOGICS 4.1 Bone Growth Factors 4.1.1 Bone Morphogenetic Proteins 220.127.116.11 Products 18.104.22.168.1 Infuse Bone Graft 22.214.171.124.2 Osteogenic Protein-1 126.96.36.199 Emerging Products 188.8.131.52 Clinical Trials 4.1.2 Fibroblast Growth Factors 4.1.3 Recombinant Platelet-Derived Growth Factor 184.108.40.206 Products 4.1.4 Autologous (Blood-Derived) Growth Factors 220.127.116.11 Products 4.2 Small Molecules 4.3 Stem Cell Therapy 4.3.1 Products 4.3.2 Emerging Products 4.4 Gene Therapy 4.4.1 Gene Therapy versus Growth Factors 4.4.2 Systemic Gene Therapy 4.4.3 Regional Gene Therapy 4.5 Other Osteobiologics 4.6 Market Analysis 4.6.1 Bone Morphogenetic Proteins 4.6.2 Other Osteobiologics 4.7 Competitive Analysis Exhibit 4-1: Selected Bone Morphogenetic Proteins Exhibit 4-2: Selected Recombinant Human Bone Morphogenetic Protein Products Exhibit 4-3: Selected Recombinant Human Bone Morphogenetic Proteins Under Development Exhibit 4-4: 2013, Selected Autologous Therapy/Platelet Concentrate Systems Exhibit 4-5: 2013, Selected Growth Factor and Small Molecule Therapies Under Development for Bone Healing and Spinal Fusion Applications Exhibit 4-6: 2013, Selected Stem Cell Products for Bone Healing and Enhancement of Spinal Fusion Exhibit 4-7: 2013, Selected Stem Cell Products Under Development for Orthopedic and Spinal Fusion Applications Exhibit 4-8: Comparison of Growth Factors with Gene Therapyfor Bone Repair Exhibit 4-9: Gene Therapy Delivery Methods for Bone Repair Exhibit 4-10: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit 4-11: Stem Cells and Other Osteobiologic Agents for Bone Healing and Enhancement of Spinal Fusion, Market Forecast, 2012-2017 Exhibit 4-12: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit 4-13: 2012, Stem Cell Products Market for Bone Healing and Spinal Fusion, Share by Supplier 5. COMPANY PROFILES 5.1 Arthrex, Inc. 5.2 Baxter International, Inc. 5.3 DiFusion Technologies 5.4 Johnson & Johnson 5.5 LifeNet Health, Inc. 5.6 Medtronic, Inc. 5.7 Musculoskeletal Transplant Foundation, Inc. 5.8 NuVasive, Inc. 5.9 Orthofix International NV 5.10 RTI Biologics, Inc. 5.11 Smith & Nephew PLC 5.12 Stryker Corporation APPENDIX: COMPANY LISTING