This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for biomaterial products for bone healing/regeneration and spinal fusion indications. This market, as covered by the scope of this report, includes bioresorbable fixation devices (pins, screws, tacks, suture anchors, and meniscal repair devices); allografts and bone replacement materials (base tissue, demineralized bone matrix, machined bone allografts, and synthetic bone grafts), and osteobiologics (autologous therapy/platelet concentrate systems, gene therapy, platelet-derived growth factors, recombinant human bone morphogenetic proteins, small molecule therapies, and stem cells). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for bone repair and regeneration is projected to reach an estimated value of $3.5 billion in the year 2017.
This is the first of two reports covering the U.S. market for orthopedic biomaterials. Report #A322, "U.S. Markets for Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration" has also published.
EXECUTIVE SUMMARY i. Bioresorbable Fixation Devices ii. Bone Allograft and Synthetic Bone Graft Products iii. Osteobiologics iv. Combined Market Forecast v. Methodology Exhibit ES-1: Types of Bioresorbable Fixation Devices Exhibit ES-2: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit ES-3: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit ES-4: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit ES-6: Osteobiologics, Market Forecast, 2012-2017 Exhibit ES-7: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit ES-8: Orthopedic Biomaterials for Bone Repair and Regeneration, Combined Market Forecast, 2012-2017 1. MUSCULOSKELETAL SYSTEM OVERVIEW 1.1 Bone Structure and Function 1.1.1 Cellular Framework 184.108.40.206 Osteoblasts 220.127.116.11 Osteocytes 18.104.22.168 Osteoclasts 22.214.171.124 Osteogenesis 1.1.2 Bone Tissue 126.96.36.199 Cancellous and Cortical Bone Tissue 188.8.131.52 Bone Marrow 1.1.3 Bone Anatomy 184.108.40.206 Diaphysis and Epiphysis 220.127.116.11 Endosteum 18.104.22.168 Periosteum 1.1.4 Joint Components 22.214.171.124 Cartilage 126.96.36.199.1 Elastic Cartilage 188.8.131.52.2 Fibrocartilage 184.108.40.206.3 Hyaline Cartilage 220.127.116.11 Bursae 18.104.22.168 Joint Cavity 22.214.171.124 Menisci 126.96.36.199 Synovial Membrane and Fluid 188.8.131.52 Ligaments and Tendons 184.108.40.206 Muscles 1.1.5 Joint Structures 220.127.116.11 Ankle 18.104.22.168 Digits 22.214.171.124 Elbow 126.96.36.199 Hip 188.8.131.52 Knee 184.108.40.206 Shoulder 220.127.116.11 Wrist 1.1.6 Bone Formation and Remodeling 18.104.22.168 In the Fetus 22.214.171.124 In Childhood 126.96.36.199 In Adulthood 188.8.131.52 In Old Age 184.108.40.206 Mechanical Stress and Wolff's Law 1.1.7 Factors Affecting Bone Physiology 220.127.116.11 Age 18.104.22.168 Gender 22.214.171.124 Genetic Disposition 126.96.36.199 Hormonal Activity 188.8.131.52 Physical Activity 184.108.40.206 Cigarette Smoking 220.127.116.11 Alcohol and Caffeine Intake 18.104.22.168 Nutritional Deficiencies 1.2 Joint Structure and Function 1.2.1 Types of Joints 22.214.171.124 Synarthroses 126.96.36.199 Amphiarthroses 188.8.131.52 Diarthroses 184.108.40.206.1 Ball-and-Socket 220.127.116.11.2 Condyloid 18.104.22.168.3 Hinge 22.214.171.124.4 Gliding 126.96.36.199.5 Pivot 1.2.2 Arthritis 188.8.131.52 Osteoarthritis 184.108.40.206 Rheumatoid Arthritis 1.3 Management of Joint Disorders 1.3.1 Joint Replacement 220.127.116.11 Dislocation 18.104.22.168 Ligament and Tendon Injuries 22.214.171.124 Meniscal Injuries Exhibit 1-1: Illustration of Bone Tissue Exhibit 1-2: Types of Cartilage Exhibit 1-3: Stages of Bone Remodeling 2. BIORESORBABLE FIXATION DEVICES 2.1 Materials 2.2 Products 2.2.1 Bioresorbable Pins 2.2.2 Bioresorbable Screws, Nails, and Tacks 2.2.3 Bioresorbable Interference Screws 2.2.4 Bioresorbable Suture Anchors 2.2.5 Bioresorbable Meniscal Repair Devices 2.3 Market Analysis 2.3.1 Potential Market for Bioresorbable Fixation Devices 126.96.36.199 Meniscal Repair 188.8.131.52 Cruciate Ligament Fixation 184.108.40.206 Shoulder Reconstruction 220.127.116.11 Small Joint/Bone Fragment Fixation 2.4 Competitive Analysis Exhibit 2-1: Advantages of Bioresorbable Fixation Devices Exhibit 2-2: Factors Affecting the Properties of Bioresorbable Polymers Exhibit 2-3: Types of Bioresorbable Fixation Devices Exhibit 2-4: 2013, Selected Bioresorbable Pins Exhibit 2-5: 2013, Selected Bioresorbable Nails, Screws, and Tacks Exhibit 2-6: 2013, Selected Bioresorbable Interference Screws Exhibit 2-7: 2013, Selected Bioresorbable Suture Anchors Exhibit 2-8: 2013, Selected Bioresorbable Meniscal Repair Devices Exhibit 2-9: 2012, Bioresorbable Fixation Devices Market, By Procedure Type Exhibit 2-10: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit 2-11: 2012, Bioresorbable Fixation Devices Market, Share by Supplier 3. BONE ALLOGRAFT AND SYNTHETIC BONE GRAFT PRODUCTS 3.1 Bone Graft Materials 3.1.1 Autograft 3.1.2 Allograft 18.104.22.168 Regulations Governing Allograft Providers 22.214.171.124.1 National Organ Transplant Act 126.96.36.199.2 United States Food and Drug Administration Requirements 188.8.131.52 Donor Screening 184.108.40.206 Recovering Tissue 220.127.116.11 Processing Tissue 18.104.22.168 Tissue Banking Industry 22.214.171.124 Base Tissue 126.96.36.199 Demineralized Bone Matrix Products 188.8.131.52 Machined Bone 3.2 Synthetic Bone Grafts 3.2.1 Products 3.3 Bone Graft Applications 3.3.1 Fracture Repair 3.3.2 Revision Total Joint Surgery 3.3.3 Tumors 3.3.4 Spine 3.4 Market Analysis 3.5 Competitive Analysis 3.5.1 Demineralized Bone Matrix 3.5.2 Machined Bone Allografts 3.5.3 Synthetic Bone Graft Substitutes Exhibit 3-1: Selected Categories of Bone Grafts Exhibit 3-2: Base Tissue Bone Allograft Applications in Orthopedic Surgery Exhibit 3-3: Base Tissue Bone Allograft Applications in Spine Surgery Exhibit 3-4: 2013, Description and Representative Pricing of Base Allografts Used in Spine Surgery Exhibit 3-5: 2013, Selected Demineralized Bone Matrix Products Exhibit 3-6: 2013, Selected Machined Bone Allografts Exhibit 3-7: Materials Used in Bone Graft Substitutes Exhibit 3-8: 2013, Selected Synthetic Bone Grafts Exhibit 3-9: Applications for Bone Grafts Exhibit 3-10: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit 3-11: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit 3-12: 2012, Demineralized Bone Matrix Products Market, Share by Supplier Exhibit 3-13: 2012, Machined Bone Allografts Market, Share by Supplier Exhibit 3-14: 2012, Synthetic Bone Grafts Market, Share by Supplier 4. OSTEOBIOLOGICS 4.1 Bone Growth Factors 4.1.1 Bone Morphogenetic Proteins 184.108.40.206 Products 220.127.116.11.1 Infuse Bone Graft 18.104.22.168.2 Osteogenic Protein-1 22.214.171.124 Emerging Products 126.96.36.199 Clinical Trials 4.1.2 Fibroblast Growth Factors 4.1.3 Recombinant Platelet-Derived Growth Factor 188.8.131.52 Products 4.1.4 Autologous (Blood-Derived) Growth Factors 184.108.40.206 Products 4.2 Small Molecules 4.3 Stem Cell Therapy 4.3.1 Products 4.3.2 Emerging Products 4.4 Gene Therapy 4.4.1 Gene Therapy versus Growth Factors 4.4.2 Systemic Gene Therapy 4.4.3 Regional Gene Therapy 4.5 Other Osteobiologics 4.6 Market Analysis 4.6.1 Bone Morphogenetic Proteins 4.6.2 Other Osteobiologics 4.7 Competitive Analysis Exhibit 4-1: Selected Bone Morphogenetic Proteins Exhibit 4-2: Selected Recombinant Human Bone Morphogenetic Protein Products Exhibit 4-3: Selected Recombinant Human Bone Morphogenetic Proteins Under Development Exhibit 4-4: 2013, Selected Autologous Therapy/Platelet Concentrate Systems Exhibit 4-5: 2013, Selected Growth Factor and Small Molecule Therapies Under Development for Bone Healing and Spinal Fusion Applications Exhibit 4-6: 2013, Selected Stem Cell Products for Bone Healing and Enhancement of Spinal Fusion Exhibit 4-7: 2013, Selected Stem Cell Products Under Development for Orthopedic and Spinal Fusion Applications Exhibit 4-8: Comparison of Growth Factors with Gene Therapyfor Bone Repair Exhibit 4-9: Gene Therapy Delivery Methods for Bone Repair Exhibit 4-10: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit 4-11: Stem Cells and Other Osteobiologic Agents for Bone Healing and Enhancement of Spinal Fusion, Market Forecast, 2012-2017 Exhibit 4-12: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit 4-13: 2012, Stem Cell Products Market for Bone Healing and Spinal Fusion, Share by Supplier 5. COMPANY PROFILES 5.1 Arthrex, Inc. 5.2 Baxter International, Inc. 5.3 DiFusion Technologies 5.4 Johnson & Johnson 5.5 LifeNet Health, Inc. 5.6 Medtronic, Inc. 5.7 Musculoskeletal Transplant Foundation, Inc. 5.8 NuVasive, Inc. 5.9 Orthofix International NV 5.10 RTI Biologics, Inc. 5.11 Smith & Nephew PLC 5.12 Stryker Corporation APPENDIX: COMPANY LISTING