U.S. MARKETS FOR CURRENT AND EMERGING ORTHOPEDIC BIOMATERIALS PRODUCTS AND TECHNOLOGIES

400 Pages | 135 Exhibits | 2002 Analysis | Forecasts Through 2010

OVERVIEW:
Orthopedic biomaterials technology is taking the orthopedic industry by storm, helping to speed healing of bone, cartilage, meniscus, and ligament and tendon surgery or injury. The U.S. market for these products is booming, as diseases such as osteoporosis and injuries to the soft tissues of the joints continue to affect a growing elderly, yet still-active, population. This report details the current and emerging technologies and players impacting the markets for bone replacement materials, bone growth factors, cartilage repair, and meniscal, ligament, and tendon repair and replacement. The markets for products used in these fields and procedure volumes are forecast over the next five years and the technology is assessed over a ten-year span. In addition, detailed profiles are provided for the major market players.

TABLE OF CONTENTS:

SECTION 1:  EXECUTIVE SUMMARY

1.1 Bioresorbable Fixation Devices

1.2 Allogeneic and Synthetic Bone Replacement

1.3 Orthobiologics    

1.4 Synovial Fluid Replacement      

1.5 Cartilage Repair and Replacement

1.6 Meniscal Repair and Replacement

1.7 Ligament and Tendon Repair and Replacement

 

SECTION 2:  BIORESORBABLE FIXATION DEVICES

2.1 Synthetic Polymers

2.2 Cadaver Bone

2.3 Product Applications

2.3.1 Bioresorbable Pins

2.3.2 Bioresorbable Bone Screws, Nails, Tacks

2.3.2.1 Competitive Analysis

2.3.3 Bioresorbable Interference Screws

2.3.3.1 Competitive Analysis

2.3.4 Bioresorbable Suture Anchors

2.3.4.1 Competitive Analysis

2.3.5 Bioresorbable Meniscal Repair Devices

2.3.5.1 Competitive Analysis

2.4 Market Assessment

2.4.1 Meniscal Repair Market

2.4.2 Cruciate Ligament Fixation Market

2.4.3 Shoulder Reconstruction Market

2.4.4 Small Joint/Bone Fragment Fixation Market

2.4.5 Potential Market for Bioresorbable Fixation Devices

2.4.6 Competitive Shares

 

SECTION 3:  ALLOGENEIC AND SYNTHETIC BONE REPLACEMENT MATERIALS

3.1 Bone Biology

3.1.1 Bone Formation

3.1.2 Bone Remodeling

3.2 Bone Replacement Materials

3.2.1 Autograft

3.2.2 Allograft

3.2.2.1 Supply Constraints

3.2.2.2 Tissue Banking Industry

3.2.2.3 FDA Regulations

3.2.2.3.1 FDA vs. WRIGHT MEDICAL TECHNOLOGIES

3.2.2.3.2 FDA vs. REGENERATION TECHNOLOGIES

3.2.2.4 Base Tissues

3.2.2.5 Demineralized Bone Matrix (DBM) Products

3.2.2.6 Machined Implants

3.2.2.7 Composite Implants

3.2.3 Synthetic Materials

3.2.3.1 Types of Synthetic Materials

3.2.3.1.1 Hydroxyapatites

3.2.3.1.2 Calcium Phosphate, Calcium Sulfate Technologies

3.2.3.1.3 Polymethacrylate Cement

3.3 Indications for Bone Grafts

3.3.1 Major Orthopedic Indications

3.3.1.1 Fracture Repair

3.3.1.2 Revision Total Joint Surgery

3.3.1.3 Tumors/Bone Cysts

3.3.2 Spinal Indications

3.3.2.1 Spinal Fusion

3.3.2.1.1 Cervical Spinal Fusion

3.3.2.1.2 Lumbar Fusions

3.3.2.2 Vertebroplasty

3.4 Potential Number of Bone Grafting Procedures

3.5 Competitors

3.5.1 Allogeneic Bone Suppliers

3.5.1.1 Competitive Market Shares

3.5.1.1.1 DBM Products

3.5.1.1.2 Machined Implants

3.5.2 Synthetic Bone Replacement Segment

3.5.2.1 Competitive Market Shares

3.6 Market Assessment

 

SECTION 4:  ORTHOBIOLOGICS

4.1 Bone Growth Factors

4.1.1 Transforming Growth Factor-beta (TGF-β)

4.1.1.1 Bone Morphogenetic Proteins

4.1.1.1.1 Competitive Analysis

4.1.1.2 Recombinant BMP Technologies

4.1.1.2.1 Competitive Analysis

4.1.1.3 BMP Regulation

4.1.1.4 Potential BMP Reimbursement Issues

4.1.2 Fibroblast Growth Factors (FGF)

4.1.3 Allogeneic-Derived Growth Factors

4.1.4 Blood-Extracted Growth Factors

4.1.4.1 Competitive Analysis

4.1.5 Recombinant Platelet-Derived Growth Factor (rhPDGF)

4.2 Small Molecules

4.3 Stem Cell and Gene Therapy

4.3.1 Competitive Analysis

4.3.2 Other Companies

4.4 Strategic Partnerships and Cross-Licensing of Orthobiologic Products

4.5 Market Assessment

 

SECTION 5:  SYNOVIAL FLUID REPLACEMENT

5.1 Treatments for Osteoarthritis

5.1.1 Drug Therapy

5.1.2 Glucosamine and Chondroitin Sulfate

5.1.3 Surgery

5.1.4 Synovial Fluid Replacement

5.1.4.1 Mechanism of Action

5.1.4.2 Prescribing Physicians

5.1.4.3 Hyaluronic Acid

5.1.4.3.1 Competitive Analysis

5.1.4.3.2 Other Synovial Fluid Replacement Products

5.1.4.4 Treatment Candidates

5.1.4.5 Market Assessment

 

SECTION 6:  CARTILAGE REPAIR AND REPLACEMENT

6.1 Cartilage Structure

6.2 Cartilage Injuries

6.2.1 Current Treatments for Cartilage Injury

6.2.1.1 Corticosteroids Injections

6.2.1.2 Arthroscopic Surgical Treatments

6.3 Technologies Under Development

6.3.1 Cell-Based Approaches

6.3.1.1 Chondrocyte Transplantation

6.3.1.1.1 Competitive Analysis

6.3.1.1.2 Other Competitors

6.3.1.2 Stem Cell Technology

6.3.1.2.1 Competitive Analysis

6.3.1.3 Growth Factor Technology

6.3.1.3.1 Competitive Analysis

6.3.2 Scaffolds

6.3.2.1 Polymer-Based Scaffolds

6.3.2.1.1 Competitive Analysis

6.3.2.2 Collagen-Based Scaffolds

6.3.2.3 Other Scaffolds

6.3.3 Cartilage Resurfacing

6.4 Market Assessment

 

SECTION 7:  MENISCAL REPAIR AND REPLACEMENT

7.1 Meniscus

7.1.1 Meniscal Injuries

7.1.1.1 Traumatic Tears

7.1.1.2 Degenerative Tears

7.2 Current Treatments

7.2.1 Nonoperative Treatment

7.2.2 Partial and Complete Meniscectomy

7.2.3 Arthroscopic Suturing

7.2.3.1 "Inside-Out" � Technique (Vertical)

7.2.3.2 "Outside-In" � Technique (Horizontal)

7.2.3.3 "All-Inside" � Technique

7.3 Meniscal Repair Technologies

7.3.1 Resorbable Devices

7.3.1.1 Competitive Analysis

7.3.2 Meniscal Repair Market Assessment

7.3.2.1 Competitive Shares

7.4 Meniscal Replacement

7.4.1 Meniscal Allografts

7.4.1.1 Competitive Analysis

7.4.2 Scaffolding Technologies

7.4.3 Collagen Scaffolds

7.4.3.1 Competitive Analysis

7.4.4 Polymer Scaffolds

7.4.4.1 Competitive Analysis

7.4.5 Biological Scaffolds

7.4.5.1 Competitive Analysis

7.4.6 Gene and Cell Therapy

7.5 Meniscal Replacement and Regeneration Market Assessment

 

SECTION 8:  LIGAMENT AND TENDON REPAIR AND REPLACEMENT

8.1 Ligament and Tendon Anatomy

8.2 Types of Ligaments and Tendons

8.2.1 Knee Ligaments

8.2.1.1 Anterior Cruciate Ligament

8.2.2 Achilles Tendon

8.2.3 Hand Ligaments and Tendons

8.2.4 Shoulder Ligaments and Tendons

8.2.5 Rotator Cuff

8.3 Procedural Volumes

8.4 Current Treatments

8.4.1 ACL Tears

8.4.1.1 Autograft

8.4.1.1.1 Bone-Patella Tendon-Bone Graft

8.4.1.1.2 Hamstring Tendon Graft

8.4.1.1.3 Quadriceps Tendon Graft

8.4.1.2 Allograft

8.4.1.2.1 Allograft Transplants

8.4.2 Rotator Cuff Tears

8.4.2.1 Competitive Analysis

8.5 Emerging Technologies for Ligament and Tendon Repair

8.5.1 Biologic Scaffolds

8.5.1.1 Collagen Scaffolds

8.5.1.1.1 Competitive Analysis

8.5.1.2 Acellular Tissue Matrices

8.5.1.2.1 Competitive Analysis

8.5.1.3 Synthetic Scaffolds

8.5.1.3.1 Competitive Analysis

8.5.2 Growth Factors and Genes

8.5.2.1 Competitive Analysis

8.6 Market Assessment

8.6.1 Market Forecast

8.6.2 Market Share by Supplier

 

SECTION 9:  COMPANY PROFILES

9.1 AASTROM BIOSCIENCES, INC.

9.2 ADVANCED TISSUE SCIENCES, INC.

9.3 ARTHREX, INC.

9.4 BIOMET, INC.

9.5 BIONX IMPLANTS, INC.

9.6 CONMED CORPORATION

9.7 CRYOLIFE, INC.

9.8 ETEX CORPORATION

9.9 EXACTECH, INC.

9.10 GENSCI REGENERATION SCIENCES, INC.

9.11 GENZYME BIOSURGERY, INC.

9.12 INTEGRA LIFESCIENCES HOLDINGS CORPORATION

9.13 INTERPORE CROSS INTERNATIONAL, INC.

9.14 ISOTIS, N.V.

9.15 LIFECELL CORPORATION

9.16 MEDTRONIC, INC.

9.17 MITEK/ETHICON (A JOHNSON & JOHNSON COMPANY)

9.18 MUSCULOSKELETAL TRANSPLANT FOUNDATION

9.19 NEUCOLL, INC.

9.20 ORQUEST, INC.

9.21 ORTHOVITA, INC.

9.22 OSIRIS THERAPEUTICS

9.23 OSTEOTECH, INC.

9.24 REGEN BIOLOGICS, INC.

9.25 REGENERATION TECHNOLOGIES, INC.

9.26 SMITH & NEPHEW, PLC

9.27 STRYKER BIOTECH

9.28 SYNTHES-STRATEC, INC.

9.29 TUTOGEN MEDICAL, INC.

9.30 WRIGHT MEDICAL TECHNOLOGY

 

APPENDIX A:  COMPANY LISTING

 

LIST OF EXHIBITS

 

Exhibit 1-1:    Projected Growth of the U.S. Orthopedic Biomaterials Market, by Segment, 2001-2010E

Exhibit 1-2:    Examples of Resorbable Fixation Devices

Exhibit 1-3:    Advantages of Resorbable Fixation Devices

Exhibit 1-4:    Bioresorbable Fixation Devices, U.S. Market Forecast, 2001-2010E       

Exhibit 1-5:    2001, Bioresorbable Fixation Devices, U.S. Share by Supplier

Exhibit 1-6:    2001, Partnerships Between Allograft Suppliers/Processors and Orthopedic/Spine Companies        

Exhibit 1-7:    2001, Snapshot of the Tissue Banking Industry

Exhibit 1-8:    2001, U.S. Market for Bone Replacement Products, Share by Tissue Type  

Exhibit 1-9:    Selected Bone Morphogenetic Proteins for Orthopedic/Spinal Applications under Research and Development

Exhibit 1-10:  2002, Collaborative Efforts for the Development of Orthobiologic Products       

Exhibit 1-11:  Bone Morphogenetic Proteins for Orthopedic and Spinal Applications, U.S. Market Forecast, 2001-2010E 

Exhibit 1-12:  Other Orthobiologic Agents for Orthopedic and Spinal Applications, U.S. Market Forecast, 2001-2010E        

Exhibit 1-13:  2001, U.S. Patients with Knee Osteoarthritis        

Exhibit 1-14:  Synovial Fluid Replacement Therapy, U.S. Market Forecast, 2001-2010E

Exhibit 1-15:  2001, Selected Participants in the Knee Osteoarthritis Synovial Fluid Replacement Market 

Exhibit 1-16:  Causes of Articular Cartilage Injury 

Exhibit 1-17:  Selected Companies Developing Cartilage Repair and Replacement Products       

Exhibit 1-18:  Cartilage Repair/Regeneration, U.S. Market Forecast, 2001-2010E        

Exhibit 1-19:  2001, Companies Offering Resorbable Polymer-Based Devices for Meniscal Repair        

Exhibit 1-20:  Meniscal Repair Products, U.S. Market Forecast, 2001-2010E

Exhibit 1-21:  2001, U.S. Meniscal Repair Market, Share by Supplier

Exhibit 1-22:  Meniscal Replacement Scaffolding Products under Development in the U.S.   

Exhibit 1-23:  2001, Selected Collagen-Based Scaffolds Under Development for Ligament and Tendon Replacement in the U.S.

Exhibit 1-24:  2001, U.S. Ligament and Tendon Procedures, by Anatomical Location

Exhibit 1-25:  2001, Tendon and Ligament Replacement, U.S. Share by Supplier

Exhibit 1-26:  Tendon and Ligament Replacement Products, U.S. Market Forecast, 2001-2010E

 

Exhibit 2-1:    Advantages of Resorbable Fixation Devices

Exhibit 2-2:    2001, Polymers Commercially Available or under Development as Medical Implants

Exhibit 2-3:    Factors Affecting the Properties of Resorbable Polymeric Materials       

Exhibit 2-4:    Examples of Resorbable Fixation Devices   

Exhibit 2-5:    2001, Selected Manufacturers of Commercially Available Bioresorbable Pins   

Exhibit 2-6:    2001, Selected Manufacturers of Commercially Available Bioresorbable Bone Screws, Nails and Tacks       

Exhibit 2-7:    2001, Selected Manufacturers of Commercially Available Bioresorbable Interference Screws 

Exhibit 2-8:    2001, Selected Manufacturers of Commercially Available Bioresorbable Suture Anchors       

Exhibit 2-9:    2001, Resorbable Polymer-Based Devices for Meniscal Repair

Exhibit 2-10:  Bioresorbable Fixation Devices, Potential U.S. Procedures, 2001-2010E  

Exhibit 2-11:  2001, U.S. Market for Bioresorbable Fixation Devices

Exhibit 2-12:  Bioresorbable Fixation Devices, U.S. Market Forecast, 2001-2010E       

Exhibit 2-13:  2001, Bioresorbable Fixation Devices, U.S. Share by Supplier

 

Exhibit 3-1:    Illustration of Bone Tissue

Exhibit 3-2:    Steps in the Bone Remodeling Process      

Exhibit 3-3:    Types of Bone Grafts

Exhibit 3-4:    2001, Top Tissue Banks in the U.S.

Exhibit 3-5:    2001, Partnerships Between Allograft Suppliers/Processors and Orthopedic/Spine Companies

Exhibit 3-6:    2001, Snapshot of the Tissue Banking Industry    

Exhibit 3-7:    2001, Use of Base Tissue Bone Allografts in Orthopedic Surgery 

Exhibit 3-8:    2001, Use of Base Tissue Bone Allografts in Spine Surgery

Exhibit 3-9:    2001, Description and Representative Pricing of Base Allografts in Spine Surgery        

Exhibit 3-10:  2001, OSTEOTECH's Grafton Family of Products   

Exhibit 3-11:  2001, Demineralized Bone Matrix Products 

Exhibit 3-12:  2001, Companies Marketing Demineralized Bone Matrix-Type Products   

Exhibit 3-13:  2001, REGENERATION TECHNOLOGIES' Current and Future Allogeneic-Derived Product Offerings

Exhibit 3-14:  2001, Selected Machined Allografts by OSTEOTECH        

Exhibit 3-15:  2001, Machined Allograft Implant Products, by Supplier

Exhibit 3-16:  2001, Representative Per Procedure Pricing of Machined Allograft Implants       

Exhibit 3-17:  2001, Representative Per Procedure Pricing of Machined Allografts and DBM Products

Exhibit 3-18:  2001, Materials Used in Commercially Available Synthetic Bone Replacement Products        

Exhibit 3-19:  2001, Major Indications for Bone Grafts in Orthopedic and Spine Surgery

Exhibit 3-20:  2001, Potential U.S. Open Reduction Fracture Procedures Employing Bone Grafts   

Exhibit 3-21:  2001, Potential U.S. Revision Total Joint Procedures Employing Bone Grafts

Exhibit 3-22:  2001, Potential U.S. Tumor/Cyst Procedures Employing Bone Grafts      

Exhibit 3-23:  2001, Potential U.S. Bone Grafting Procedures in Spine Surgery

Exhibit 3-24:  2001, Potential U.S. Bone Grafting Procedures in Orthopedic/Spine Surgery        

Exhibit 3-25:  2001, Developers of Allogeneic Bone-Derived Products

Exhibit 3-26:  2001, U.S. Retail Sales and Shares of DBM Products, by Brand

Exhibit 3-27:  2001 U.S. Retail Sales and Shares of DBM Products, by Distributor

Exhibit 3-28:  2001, U.S. Market for Machined Allogeneic Implants, Share by Supplier

Exhibit 3-29:  2001, Developers of Synthetic Bone Replacement Products

Exhibit 3-30:  2001, U.S. Market for Synthetic Bone Replacement Products, Share by Supplier

Exhibit 3-31:  2001, U.S. Market for Bone Replacement Products, Share by Tissue Type

Exhibit 3-32:  Allogeneic and Synthetic Bone Replacement Products, U.S. Market Forecast, 2001-2010E

 

Exhibit 4-1:    The TGF-b Superfamily

Exhibit 4-2:    2002, Selected Bone Morphogenetic Proteins for Orthopedic Applications under Research and Development

Exhibit 4-3:    MSD's InFUSE vs. Control for Lumbar Fusion at 24-Month Follow-Up     

Exhibit 4-4:    2002, Selected Growth Factors for Orthopedic Applications Available and under Research and Development

Exhibit 4-5:    Comparison of Growth Factors and Gene Therapy for Bone Repair         

Exhibit 4-6:    2001, Gene Therapy Delivery Methods for Bone Repair

Exhibit 4-7:    2002, Selective Orthopedic Stem Cell and Gene Therapy Products under Research and Development  

Exhibit 4-8:    2002, Collaborative Efforts for the Development of Orthobiologic Products       

Exhibit 4-9:    Open Reduction Fracture and Spinal Fusion Procedures, Potential U.S. Procedures, 2001-2010E     

Exhibit 4-10:  Bone Morphogenetic Proteins for Orthopedic and Spinal Applications, Potential U.S. Market, 2001-2010E 

Exhibit 4-11:  Other Orthobiologic Agents for Orthopedic and Spinal Applications, Potential U.S. Market, 2001-2010E

Exhibit 4-12:  Bone Morphogenetic Proteins for Orthopedic and Spinal Applications, U.S. Market Forecast, 2001-2010E 

Exhibit 4-13:  Other Orthobiologic Agents for Orthopedic and Spinal Applications, U.S. Market Forecast, 2001-2010E        

 

Exhibit 5-1:    Nonpharmacologic Therapy for Patients with Osteoarthritis of the Knee and Hip        

Exhibit 5-2:    2001, Major Prescribers of Hyaluronic Acid-Injection Therapy

Exhibit 5-3:    2001, Users of Hyaluronic Acid Injection Therapy, by Specialty

Exhibit 5-4:    Effects of Hyaluronic Acid Therapy 

Exhibit 5-5:    2001, Selected Participants in the Knee Osteoarthritis Synovial Fluid Replacement Market 

Exhibit 5-6:    2001, U.S. Patients with Knee Osteoarthritis       

Exhibit 5-7:    U.S. Candidates for Synovial Fluid Replacement Therapy in the Knee, 2001-2010E  

Exhibit 5-8:    Synovial Fluid Replacement Products, U.S. Sales Forecast, 2001-2006E 

Exhibit 5-9:    Synovial Fluid Replacement Therapy, U.S. Market Forecast, 2001-2010E

Exhibit 5-10:  Synovial Fluid Replacement Therapy, Potential U.S. Market, 2001-2010E

Exhibit 5-11:  2001, U.S. Synovial Fluid Replacement Market, Share by Supplier

 

Exhibit 6-1:    Causes of Articular Cartilage Injury 

Exhibit 6-2:    Classification of Chondral Damage--The Outerbridge Classification System        

Exhibit 6-3:    Prognostic Factors for Arthroscopic Debridement of the Knee     

Exhibit 6-4:    2001E, U.S. Knee Procedures Performed for Cartilage-Related Problems 

Exhibit 6-5:    2001, Selected Companies Developing Cartilage Repair and Replacement Products       

Exhibit 6-6:    2001, Selected Companies Developing Chondrocyte Transplantation Products       

Exhibit 6-7:    2001, Selected Companies Developing Stem Cell-Based Products for Cartilage Repair       

Exhibit 6-8:    2001, Selected Companies with Polymer-Based Scaffolds for Cartilage Repair under Development

Exhibit 6-9:    2001, Selected Companies with Collagen-Based Scaffolds for Cartilage Repair under Development

Exhibit 6-10:  2001, Selected Companies with Other Scaffold Materials for Cartilage Repair under Development

Exhibit 6-11:  2001, Selected Companies with Cartilage Resurfacing Products in Development 

Exhibit 6-12:  U.S. Knee Procedures Performed for Cartilage-Related Problems, 2001E-2010E 

Exhibit 6-13:  Cartilage Repair/ Regeneration, U.S. Market Forecast, 2001-2010E       

Exhibit 6-14:  Cartilage Repair/ Regeneration, Potential U.S. Market Forecast, 2001-2010E 

 

Exhibit 7-1:    Illustration of a Healthy Knee        

Exhibit 7-2:    Illustration of a Meniscus Tear       

Exhibit 7-3:    Primary Care Diagnosis and Management of Suspected Meniscal Tears  

Exhibit 7-4:    Comparison of Treatment Options for Meniscal Injuries    

Exhibit 7-5:    2001, Companies Offering Resorbable Polymer-Based Devices for Meniscal Repair

Exhibit 7-6:    Meniscal Repair Products, U.S. Market Forecast, 2001-2010E

Exhibit 7-7:    Meniscal Repair Products, Potential U.S. Market Forecast, 2001-2010E  

Exhibit 7-8:    2001, U.S. Meniscal Repair Market, Share by Supplier

Exhibit 7-9:    2001, Meniscal Replacement Products Available in the U.S.

Exhibit 7-10:  2001, Meniscal Replacement Scaffolding Products under Development in the U.S.

Exhibit 7-11:  Meniscal Replacement and Regeneration, U.S. Market Forecast, 2001-2010E 

Exhibit 7-12:  Meniscal Replacement and Regeneration, Potential U.S. Market Forecast, 2001-2010E        

Exhibit 7-13:  2001, Acquisitions or Strategic Alliances in the Meniscal Replacement Market

 

Exhibit 8-1:    Anatomy of the Knee Joint

Exhibit 8-2:    Achilles Tendon and Other Foot and Calf Structures       

Exhibit 8-3:    Ligaments of the Hand

Exhibit 8-4:    Anatomy of the Shoulder

Exhibit 8-5:    2001, U.S. Ligament and Tendon Procedures, by Anatomical Location   

Exhibit 8-6:    Surgical Options for ACL Repair

Exhibit 8-7:    2001, Selected Companies Offering Ligament and Tendon Allografts in the U.S.       

Exhibit 8-8:    2001, Selected Collagen-Based Scaffolds under Development for Ligament and Tendon Replacement in the U.S.     

Exhibit 8-9:    2001, Selected Acellular Tissue Matrices under Development for Ligament and Tendon Replacement in the U.S.     

Exhibit 8-10:  2001, Polymer-Based Scaffolds for Ligament and Tendon Replacement under Development in the U.S.      

Exhibit 8-11:  2001, Selected Growth Factor Technologies under Development in the U.S.   

Exhibit 8-12:  Tendon and Ligament Replacement Products, U.S. Market Forecast, 2001-2010E

Exhibit 8-13:  2001, Tendon and Ligament Replacement Products, U.S. Share



COMPANIES COVERED:

  1. AASTROM BIOSCIENCES, INC.
  2. ADVANCED TISSUE SCIENCES, INC.
  3. ARTHREX, INC.
  4. BIOMET, INC.
  5. BIONX IMPLANTS, INC.
  6. CONMED CORPORATION
  7. CRYOLIFE, INC.
  8. ETEX CORPORATION
  9. EXACTECH, INC.
  10. GENSCI REGENERATION SCIENCES, INC.
  11. GENZYME BIOSURGERY, INC.
  12. INTEGRA LIFESCIENCES HOLDINGS CORPORATION
  13. INTERPORE CROSS INTERNATIONAL, INC.
  14. ISOTIS, N.V.
  15. LIFECELL CORPORATION
  16. MEDTRONIC, INC.
  17. MITEK/ETHICON (A JOHNSON & JOHNSON COMPANY)
  18. MUSCULOSKELETAL TRANSPLANT FOUNDATION
  19. NEUCOLL, INC.
  20. ORQUEST, INC.
  21. ORTHOVITA, INC.
  22. OSIRIS THERAPEUTICS
  23. OSTEOTECH, INC.
  24. REGEN BIOLOGICS, INC.
  25. REGENERATION TECHNOLOGIES, INC.
  26. SMITH & NEPHEW, PLC
  27. STRYKER BIOTECH
  28. SYNTHES-STRATEC, INC.
  29. TUTOGEN MEDICAL, INC
  30. WRIGHT MEDICAL TECHNOLOGY
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